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TG3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Drug Derivative (1)

2

Inhibitors & Agonists

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Human epidermal transglutaminase TG3; TGase 3	Biochemical Assay Reagents	Others
Human epidermal transglutaminase (TG3) is a transferase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

TG3-95-1	Drug Derivative	Others
TG3-95-1 is an active compound.

Cat. No.	Compare	Product Name	Species	Source

	Transglutaminase 3/TGM3 Protein, Human (sf9, His) Protein-glutamine gamma-glutamyltransferase E; Transglutaminase E; TGase-3	Human	Sf9 insect cells
	Transglutaminase 3 (TGM3) serves as a catalyst in the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in diverse proteins, alongside mediating the conjugation of polyamines to proteins. This enzymatic activity plays a crucial role in the intricate process of cornified envelope (CE) formation, a specialized structure comprising covalent cross-links of proteins beneath the plasma membrane in fully differentiated keratinocytes. TGM3 is actively involved in cross-linking small proline-rich proteins (SPRR1 and SPRR2) and loricrin (LOR) to create small interchain oligomers. These oligomers are subsequently cross-linked by TGM1 onto the developing CE scaffold, contributing to the structural integrity of this vital component. Notably, TGM3's involvement extends to hair follicles, where it participates in cross-linking structural proteins to fortify the inner root sheath. Transglutaminase 3/TGM3 Protein, Human (sf9, His) is the recombinant human-derived Transglutaminase 3/TGM3 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Transglutaminase 3/TGM3 Protein, Human (sf9, His) is 692 a.a., with molecular weight of ~70 kDa.

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