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Results for "

TNP

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-110079
    TNP

    		IPK Superfamily Cancer
    TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization[1][2][3].
    TNP
  • HY-101932
    TNP-470
    1 Publications Verification

    AGM-1470

    		 Aminopeptidase Cardiovascular Disease Cancer
    TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.
    TNP-470
  • HY-108667
    TNP-ATP triethylammonium

    		P2X Receptor Others
    TNP-ATP triethylammonium is a selective P2X receptor antagonist. TNP-ATP triethylammonium shows antinociceptive effects in rats .
    TNP-ATP triethylammonium
  • HY-144300
    Rifasutenizol

    TNP-2198

    		 Bacterial Infection
    Rifasutenizol (TNP-2198) is a dual-targeted antibacterial agent that has a good antibacterial effect on Helicobacter pylori infection. Rifasutenizol can be used in the study of microaerophilic and anaerobic bacterial infections .
    Rifasutenizol
  • HY-19095
    TNP-351

    		Antifolate Cancer
    TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo .
    TNP-351
  • HY-RS14857
    TNP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TNP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TNP1 Human Pre-designed siRNA Set A
    TNP1 Human Pre-designed siRNA Set A
  • HY-RS14858
    TNP2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TNP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TNP2 Human Pre-designed siRNA Set A
    TNP2 Human Pre-designed siRNA Set A
  • HY-135184
    Rifaquizinone

    CBR-2092; TNP-2092

    		 Antibiotic Bacterial DNA/RNA Synthesis Infection
    Rifaquizinone (CBR-2092) is a Rifamycin-Quinolone Hybrid Antibiotic. Rifaquizinone inhibits wild-type S. aureus RNA polymerase with an IC50 of 34 nM. Rifaquizinone is effective against S. aureus infections, with MICs ranged from 0.008 to 0.5 μg/mL for 300 clinical isolates of staphylococci and streptococci .
    Rifaquizinone
  • HY-111782
    8-Mercaptoguanosine

    8-Thioguanosine

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll .
    8-Mercaptoguanosine

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