2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. 8-Mercaptoguanosine

8-Mercaptoguanosine  (Synonyms: 8-Thioguanosine)

Cat. No.: HY-111782
Data Sheet Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll.

For research use only. We do not sell to patients.

8-Mercaptoguanosine Chemical Structure

8-Mercaptoguanosine Chemical Structure

CAS No. : 26001-38-7

Size Price Stock
10 mM * 1 mL in DMSO Ask For Quote & Lead Time
50 mg Ask For Quote & Lead Time
100 mg Ask For Quote & Lead Time
250 mg Ask For Quote & Lead Time

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Description

8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll[1][2].

Molecular Weight

315.31

Formula

C10H13N5O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(NC1=O)=NC2=C1NC(N2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (158.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1715 mL 15.8574 mL 31.7148 mL
5 mM 0.6343 mL 3.1715 mL 6.3430 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1715 mL 15.8574 mL 31.7148 mL 79.2871 mL
5 mM 0.6343 mL 3.1715 mL 6.3430 mL 15.8574 mL
10 mM 0.3171 mL 1.5857 mL 3.1715 mL 7.9287 mL
15 mM 0.2114 mL 1.0572 mL 2.1143 mL 5.2858 mL
20 mM 0.1586 mL 0.7929 mL 1.5857 mL 3.9644 mL
25 mM 0.1269 mL 0.6343 mL 1.2686 mL 3.1715 mL
30 mM 0.1057 mL 0.5286 mL 1.0572 mL 2.6429 mL
40 mM 0.0793 mL 0.3964 mL 0.7929 mL 1.9822 mL
50 mM 0.0634 mL 0.3171 mL 0.6343 mL 1.5857 mL
60 mM 0.0529 mL 0.2643 mL 0.5286 mL 1.3215 mL
80 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9911 mL
100 mM 0.0317 mL 0.1586 mL 0.3171 mL 0.7929 mL
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8-Mercaptoguanosine Related Classifications

Keywords:

8-Mercaptoguanosine26001-38-78-ThioguanosineToll-like Receptor (TLR)Inhibitorinhibitorinhibit

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