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TOP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (1) Small Interfering RNA (siRNA) (4) Topoisomerase (4)
By Research Areas:	Cancer (5)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

LMP517 NSC 781517	Topoisomerase	Cancer
LMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual *TOP1* and *TOP2* inhibitor. LMP517 shows better antitumor activity than its parent compound LMP744 (HY-U00248) against H82 (Small Cell Lung Cancer) xenografts. LMP517 induces TOP1 cleavage complexes (TOP1ccs) and TOP2ccs .

PluriSIn #2 1 Publications Verification	Topoisomerase	Cancer
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs) .

TOP2A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TOP2A Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP2A Human Pre-designed siRNA Set A TOP2A Human Pre-designed siRNA Set A

Top2a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Top2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Top2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Top2a Mouse Pre-designed siRNA Set A Top2a Mouse Pre-designed siRNA Set A

Top2a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Top2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Top2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Top2a Rat Pre-designed siRNA Set A Top2a Rat Pre-designed siRNA Set A

TOP2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TOP2B Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP2B Human Pre-designed siRNA Set A TOP2B Human Pre-designed siRNA Set A

T638	Topoisomerase	Cancer
T638 is a topoisomerase II (TOP2) inhibitor. T638 inhibits *TOP2A* activity with a IC₅₀ of 0.7 uM. T638 strongly inhibits cancer cell growth .

BNS-22	Topoisomerase	Cancer
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC₅₀ values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .

Ametantrone NSC 196473; NSC 290813	DNA/RNA Synthesis	Cancer
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break .

Cat. No.	Compare	Product Name	Application	Reactivity

	TOP2A Antibody DNA TOPoisomerase II; DNA TOPoisomerase II-alpha; TOP2; TP2A; alpha isozyme, TOPoisomerase II alpha	WB, IHC-P, IP	Human, Mouse, Rat
	TOP2A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 174 kDa, targeting to TOP2A. It can be used for WB, IHC-P, IP assays with tag free, in the background of Human, Mouse, Rat.

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TOP2A Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TOP2A Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Top2a Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Top2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Top2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Top2a Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Top2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Top2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP2B Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TOP2B Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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