2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. LMP517

LMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual TOP1 and TOP2 inhibitor. LMP517 shows better antitumor activity than its parent compound LMP744 (HY-U00248) against H82 (Small Cell Lung Cancer) xenografts. LMP517 induces TOP1 cleavage complexes (TOP1ccs) and TOP2ccs.

For research use only. We do not sell to patients.

LMP517 Chemical Structure

LMP517 Chemical Structure

CAS No. : 1883730-99-1

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5 mg USD 680 In-stock
10 mg USD 1100 In-stock
25 mg USD 2300 In-stock
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Based on 1 publication(s) in Google Scholar

LMP517 Related Antibodies

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual TOP1 and TOP2 inhibitor. LMP517 shows better antitumor activity than its parent compound LMP744 (HY-U00248) against H82 (Small Cell Lung Cancer) xenografts. LMP517 induces TOP1 cleavage complexes (TOP1ccs) and TOP2ccs[1].

IC50 & Target

Topoisomerase I

 

Topoisomerase II

 

Cellular Effect
Cell Line Type Value Description References
DU-145 GI50
0.033 μM
Compound: 29
Cytotoxicity against human DU145 cells by MTT assay
Cytotoxicity against human DU145 cells by MTT assay
[PMID: 26906474]
HCT-116 GI50
0.019 μM
Compound: 29
Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
[PMID: 26906474]
HOP-62 GI50
0.036 μM
Compound: 29
Cytotoxicity against human HOP62 cells by MTT assay
Cytotoxicity against human HOP62 cells by MTT assay
[PMID: 26906474]
MCF7 GI50
< 0.01 μM
Compound: 29
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
[PMID: 26906474]
OVCAR-3 GI50
0.076 μM
Compound: 29
Cytotoxicity against human OVCAR3 cells by MTT assay
Cytotoxicity against human OVCAR3 cells by MTT assay
[PMID: 26906474]
SF-539 GI50
0.041 μM
Compound: 29
Cytotoxicity against human SF539 cells by MTT assay
Cytotoxicity against human SF539 cells by MTT assay
[PMID: 26906474]
SN12C GI50
0.107 μM
Compound: 29
Cytotoxicity against human SN12C cells by MTT assay
Cytotoxicity against human SN12C cells by MTT assay
[PMID: 26906474]
UACC-62 GI50
0.028 μM
Compound: 29
Cytotoxicity against human UACC62 cells by MTT assay
Cytotoxicity against human UACC62 cells by MTT assay
[PMID: 26906474]
Molecular Weight

410.40

Formula

C22H19FN2O5
CAS No.
Appearance

Solid

Color

Deep purple to brown

SMILES

O=C1C2=CC3=C(C=C2C4=C1C5=C(C(N4CCCNCCO)=O)C=C(F)C=C5)OCO3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 44 mg/mL (107.21 mM; ultrasonic and adjust pH to 1 with TFA; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4366 mL 12.1832 mL 24.3665 mL
5 mM 0.4873 mL 2.4366 mL 4.8733 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

SDS (251 KB)

COA (254 KB) HNMR (172 KB) RP-HPLC (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4366 mL 12.1832 mL 24.3665 mL 60.9162 mL
5 mM 0.4873 mL 2.4366 mL 4.8733 mL 12.1832 mL
10 mM 0.2437 mL 1.2183 mL 2.4366 mL 6.0916 mL
15 mM 0.1624 mL 0.8122 mL 1.6244 mL 4.0611 mL
20 mM 0.1218 mL 0.6092 mL 1.2183 mL 3.0458 mL
25 mM 0.0975 mL 0.4873 mL 0.9747 mL 2.4366 mL
30 mM 0.0812 mL 0.4061 mL 0.8122 mL 2.0305 mL
40 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5229 mL
50 mM 0.0487 mL 0.2437 mL 0.4873 mL 1.2183 mL
60 mM 0.0406 mL 0.2031 mL 0.4061 mL 1.0153 mL
80 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7615 mL
100 mM 0.0244 mL 0.1218 mL 0.2437 mL 0.6092 mL
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LMP517 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LMP5171883730-99-1NSC 781517LMP 517LMP-517NSC781517NSC-781517TopoisomeraseInhibitorinhibitorinhibit

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