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Results for "

TRPC4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Small Interfering RNA (siRNA) (2) TRP Channel (13)
By Research Areas:	Cancer (4) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (5)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132813

Evifacotrep	TRP Channel	Neurological Disease
Evifacotrep, a short transient receptor potential channel 5 and 4 (TRPC5/TRPC4) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to *TRPC5/TRPC4* with IC₅₀s ≤50 nM .

HY-133168

Englerin A	TRP Channel	Cancer
Englerin A is a potent and selective activator of *TRPC4* and *TRPC5* channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca ²⁺ influx and Ca ²⁺ cell overload .

HY-112302

HC-070 4 Publications Verification	TRP Channel	Neurological Disease
HC-070 is an antagonist of *TRPC4/TRPC5, with IC₅₀*s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively.

HY-12949

ML204 4 Publications Verification	TRP Channel	Neurological Disease
ML204 is a potent, selective *TRPC4/TRPC5* channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

HY-RS15106

TRPC4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPC4 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPC4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPC4 Human Pre-designed siRNA Set A TRPC4 Human Pre-designed siRNA Set A

HY-146155

TRPC4/5-IN-1	TRP Channel	Metabolic Disease Inflammation/Immunology
TRPC4/5-IN-1 is a potent TRP channel 4/5 (TRPC4/5) inhibitor with IC₅₀s of 2.06 μM and 0.54 μM, respectively. TRPC4/5-IN-1 can be used for proteinuric kidney diseases and skin inflammatory diseases research .

HY-162584

TRPC4/5-IN-2	TRP Channel	Others
TRPC4/5-IN-2 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC₅₀ value of 81 nM. TRPC4/5-IN-2 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD) .

HY-RS15107

TRPC4AP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPC4AP Human Pre-designed siRNA Set A contains three designed siRNAs for TRPC4AP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPC4AP Human Pre-designed siRNA Set A TRPC4AP Human Pre-designed siRNA Set A

HY-133168R

Englerin A (Standard)	TRP Channel	Cancer
Englerin A (Standard) is the analytical standard of Englerin A. This product is intended for research and analytical applications. Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload .

HY-110379

M084 hydrochloride	TRP Channel	Neurological Disease
M084 hydrochloride is a *TRPC4/5* channel blocker, with IC₅₀ values of 10.3 μM and 8.2 μM, respectively. M084 hydrochloride has antidepressant and anxiolytic effects .

HY-12949A

ML204 hydrochloride 4 Publications Verification	TRP Channel	Neurological Disease
ML204 hydrochloride is a novel, potent, selective *TRPC4/TRPC5* channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

HY-162090

TRPC antagonist 1	TRP Channel	Cancer
TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC₅₀s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines .

HY-101507

Pico145 Maximum Cited Publications 7 Publications Verification HC-608	TRP Channel	Cancer
Pico145 (HC-608) is a remarkable inhibitor of *TRPC1/4/5* channels, inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC₅₀s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

HY-122051

AC1903 1 Publications Verification	TRP Channel	Metabolic Disease
AC1903 is a specific and selective inhibitor of *TRPC5* and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model .

HY-144429

TRPC5-IN-4	TRP Channel	Metabolic Disease
TRPC5-IN-4 is potent and safe *TRPC* inhibitor with IC₅₀ value of 14.07 nM and 65 nM for *TRPC5* and *TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC*5-IN-4 can be used for the research of chronic kidney disease (CKD) .

Englerin A	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Cancer	TRP Channel
Englerin A is a potent and selective activator of *TRPC4* and *TRPC5* channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca ²⁺ influx and Ca ²⁺ cell overload .

Englerin A (Standard)	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	TRP Channel
Englerin A (Standard) is the analytical standard of Englerin A. This product is intended for research and analytical applications. Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload .

TRPC4 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TRPC4 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPC4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPC4AP Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TRPC4AP Human Pre-designed siRNA Set A contains three designed siRNAs for TRPC4AP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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