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TX2-121-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-118998
    TX2-121-1

    		PROTACs EGFR ERK Akt Cancer
    TX2-121-1 is a potent and selective Her3 (ErbB3) PROTAC degrader that contains a hydrophobic adamantane moiety. TX2-121-1 is composed of a Her3 inhibitor (HY-164988) and Adamantane (HY-N2427). TX2-121-1 has an IC50 of 49 nM for Her3. TX2-121-1 inhibits Her3-dependent signaling and heterodimerization of Her3. TX2-121-1 has the ability to inhibit cell proliferation. TX2-121-1 can be used in the study of tumors .
    TX2-121-1
  • HY-164988
    TX2-120-1

    		EGFR Cancer
    TX2-120-1 possesses the ability to bind to Her3, with an IC50 value of 56 nM for Her3. TX2-120-1 can be used for the synthesis of TX2-121-1 (HY-118998) .
    TX2-120-1

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