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Topoisomerase IIα-IN-10

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-170557
    Topoisomerase IIα-IN-10

    		Topoisomerase Apoptosis Mitochondrial Metabolism Cancer
    Topoisomerase IIα-IN-10 (Compound 13r) is an inhibitor of Topoisomerase IIα. It binds to the active site of DNA when complexed with Topoisomerase IIα, and this binding is stabilized through interactions with DNA base pairs and amino acid residues. Topoisomerase IIα-IN-10 can induce Apoptosis by intercalating DNA and inhibiting Topoisomerase IIα, thereby disrupting the mitochondrial membrane potential and inhibiting the growth of HCT116 cell lines, with an IC50 of 4.37 μM against HCT116 cells. Topoisomerase IIα-IN-10 can be used for research in the field of cancer treatment .
    Topoisomerase IIα-IN-10

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