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TrimTAC-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169355
    TrimTAC1

    		PROTACs
    TrimTAC1 is a PROTAC degrader that selectively targets the degradation of the multimeric protein Nucleoporin [1]. TrimTAC1 is composed of PROTAC target protein ligand (red part) (+)-JQ-1 (HY-13030), E3 ligase ligand (blue part) Acepromazine-OTs (HY-169356) and PROTAC linker (black part) tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate (HY-W088456). Among them, its E3 ligase ligand + linker can form Acepromazine-1-Piperazinepropanamine (HY-169357).
    TrimTAC1
  • HY-W088456
    tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate

    		PROTAC Linkers Cancer
    tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate is a linker that can be used for synthesis of PROTAC degrader TrimTAC1 (HY-169355) [1].
    tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate
  • HY-169356
    Acepromazine-OTs

    		Ligands for E3 Ligase Cancer
    Acepromazine-OTs is a cereblon (CRBN) ligand used in the recruitment of the cereblon (CRBN) protein. Acepromazine-OTs can be connected to the target protein ligand through a linker to form a PROTAC molecule, TrimTAC1 (HY-169355) [1].
    Acepromazine-OTs
  • HY-169357
    Acepromazine-1-Piperazinepropanamine

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Acepromazine-1-Piperazinepropanamine (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a cereblon ligand and a linker. Acepromazine-1-Piperazinepropanamine can be connected to the target protein ligand to form a PROTAC molecule, TrimTAC1 (HY-169355) [1].
    Acepromazine-1-Piperazinepropanamine

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