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Tubulin/PARP-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-157165
    Tubulin/PARP-IN-1

    		Microtubule/Tubulin PARP Cancer
    Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase .
    Tubulin/PARP-IN-1
  • HY-163983
    Tubulin polymerization-IN-68

    		Microtubule/Tubulin Apoptosis PARP Caspase Cancer
    Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration .
    Tubulin polymerization-IN-68

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