2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis Epigenetics
  3. Microtubule/Tubulin Apoptosis PARP Caspase
  4. Tubulin polymerization-IN-68

Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration.

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Tubulin polymerization-IN-68 Chemical Structure

Tubulin polymerization-IN-68 Chemical Structure

CAS No. : 2924156-96-5

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Tubulin polymerization-IN-68 Related Antibodies

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Description

Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1].

IC50 & Target

PARP-1[1]
Molecular Weight

263.29

Formula

C16H13N3O
CAS No.
SMILES

O=C1NC(C2=CC3=C(NC=C3)C=C2)NC4=C1C=CC=C4
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Tubulin polymerization-IN-68 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-682924156-96-5Microtubule/TubulinApoptosisPARPCaspasepoly ADP ribose polymeraseInhibitorinhibitorinhibit

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