VEGFC

By Targets:	Akt (1) Apoptosis (1) Bacterial (1) HIF/HIF Prolyl-Hydroxylase (1) PI3K (1) Small Interfering RNA (siRNA) (3) Tie (1) VEGFR (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990675

VGX-100	VEGFR	Inflammation/Immunology
VGX-100 is a humanized antibody expressed in CHO cells, targeting *VEGFC*. VGX-100 is composed of huIgG1 heavy chains and huλ light chains, with a predicted molecular weight (MW) of 143.6 kDa. The isotype control for VGX-100 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P9920A

Ramucirumab (anti-VEGFR)	VEGFR	Cancer
Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .

HY-P3369

Gersizangitide AXT-107	VEGFR Tie Akt	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of *VEGF-A* and *VEGF-C* and an activator of Tie2. Gersizangitide can block *VEGF* receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis .

HY-N2187

Deoxyshikonin 2 Publications Verification	Bacterial HIF/HIF Prolyl-Hydroxylase PI3K Apoptosis	Infection Cardiovascular Disease Cancer
Deoxyshikonin increases the expression of *VEGF-C* and *VEGF-A* mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL) .

HY-RS15637

VEGFC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VEGFC Human Pre-designed siRNA Set A contains three designed siRNAs for VEGFC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VEGFC Human Pre-designed siRNA Set A VEGFC Human Pre-designed siRNA Set A

HY-RS23109

Vegfc Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vegfc Rat Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vegfc Rat Pre-designed siRNA Set A Vegfc Rat Pre-designed siRNA Set A

HY-RS16674

Vegfc Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vegfc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vegfc Mouse Pre-designed siRNA Set A Vegfc Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P3369

Gersizangitide AXT-107	VEGFR Tie Akt	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of *VEGF-A* and *VEGF-C* and an activator of Tie2. Gersizangitide can block *VEGF* receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis .

Cat. No.	Product Name	Target	Research Area

HY-P990675

VGX-100	VEGFR	Inflammation/Immunology
VGX-100 is a humanized antibody expressed in CHO cells, targeting *VEGFC*. VGX-100 is composed of huIgG1 heavy chains and huλ light chains, with a predicted molecular weight (MW) of 143.6 kDa. The isotype control for VGX-100 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P9920A

Ramucirumab (anti-VEGFR)	VEGFR	Cancer
Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2187

Deoxyshikonin 2 Publications Verification	Infection Cardiovascular Disease Quinones Structural Classification Classification of Application Fields Plants Naphthalene Quinones Boraginaceae Disease Research Fields Arnebia euchroma (Royle) Johnst.	Bacterial HIF/HIF Prolyl-Hydroxylase PI3K Apoptosis
Deoxyshikonin increases the expression of *VEGF-C* and *VEGF-A* mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL) .

Recombinant Proteins Recommended:

VEGF-C

Species:	Human (5) Mouse (2) Rat (2)
Tag:	His (5) Tag Free (1) Avi (2) Fc (1)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P70501

	VEGF-CC Protein, Human (196a.a, HEK293, His) Vascular Endothelial Growth Factor C; VEGF-C; Flt4 Ligand; Flt4-L; Vascular Endothelial Growth Factor-Related Protein; VRP; VEGFC	Human	HEK293
	The VEGF-CC protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-CC Protein, Human (196a.a, HEK293, His) is the recombinant human-derived VEGF-CC protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74474

	VEGF-CC Protein, Mouse/Rat (HEK293, His) 1 Publications Verification Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Mouse;Rat	HEK293
	VEGF-CC protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-CC Protein, Mouse/Rat (HEK293, His) is the recombinant mouse, rat-derived VEGF-CC protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74475

	VEGF-CC Protein, Mouse/Rat (HEK293, Fc) Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Rat;Mouse	HEK293
	VEGF-CC protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-CC Protein, Mouse/Rat (HEK293, Fc) is the recombinant rat, mouse-derived VEGF-CC protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P73529

	VEGF-CC Protein, Human (125a.a, HEK293, His) Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Human	HEK293
	The VEGF-CC protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-CC Protein, Human (125a.a, HEK293, His) is the recombinant human-derived VEGF-CC protein, expressed by HEK293 , with C-His labeled tag.

HY-P77864

	VEGF-C Protein, Human (HEK293, His-Avi) VEGFC; VEGF-CC; VEGFC; Flt4-L; VRP;	Human	HEK293
	VEGF-C protein is an important member of the PDGF/VEGF growth factor family and plays a role in important cell signaling pathways. As part of this family, VEGF-C may share features with related proteins that promote cell growth, angiogenesis, and lymphangiogenesis. VEGF-C Protein, Human (HEK293, His-Avi) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P77865

	VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) VEGFC; VEGF-CC; VEGFC; Flt4-L; VRP;	Human	HEK293
	VEGF-C protein is an important member of the PDGF/VEGF growth factor family and plays a role in important cell signaling pathways. As part of this family, VEGF-C may share features with related proteins that promote cell growth, angiogenesis, and lymphangiogenesis. VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P7313

	VEGF-CC Protein, Human (116a.a, HEK293) rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP	Human	HEK293
	VEGF-C Protein, Human (116a.a, HEK293) functions in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration.

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Cat. No.	Product Name		Classification

HY-RS15637

VEGFC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VEGFC Human Pre-designed siRNA Set A contains three designed siRNAs for VEGFC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23109

Vegfc Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Vegfc Rat Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16674

Vegfc Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Vegfc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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