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Results for "

anti-melanogenic

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

9

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1238
    β-Sitostenone

    Δ4-Sitosterol-3-one; β-Rosasterol oxide

    		 Tyrosinase Endogenous Metabolite Cancer
    β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities .
    β-Sitostenone
  • HY-N6244
    Isolindleyin

    		Tyrosinase Inflammation/Immunology
    Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a Kd of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities .
    Isolindleyin
  • HY-W037976
    Tyrosinase-IN-22

    5-Chloro-2-mercaptobenzimidazole

    		 Reactive Oxygen Species Tyrosinase Cancer
    Tyrosinase-IN-22 (compound 4) is an inhibitor of tyrosinase substrates (L-tyrosine and L-dopa) with IC50s of 60 nM and 30 nM, respectively. Tyrosinase-IN-22 also shows potent antioxidant and anti-melanogenic properties, thus can be used for relevant researches .
    Tyrosinase-IN-22
  • HY-126562
    Piperlonguminine

    		Bacterial Fungal Antibiotic Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows various biological properties, including anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities .
    Piperlonguminine
  • HY-N1481
    Methyl linoleate

    		Tyrosinase Metabolic Disease
    Methyl linoleate, a major active constituent of Sageretia thea?fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF)?and tyrosinase-related proteins .
    Methyl linoleate
  • HY-N2983
    Cajanin

    		Tyrosinase Others
    Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis .
    Cajanin
  • HY-N9316
    3'-Deoxy-4-O-methylsappanol

    		Others Cancer
    3'-Deoxy-4-O-methylsappanol shows cytotoxicity against melanoma HMV II cell (IC50=50.4 μM) and has significant anti-melanogenic activities (EC50=72 μM) .
    3'-Deoxy-4-O-methylsappanol
  • HY-N1481R
    Methyl linoleate (Standard)

    		Tyrosinase Metabolic Disease
    Methyl linoleate (Standard) is the analytical standard of Methyl linoleate. This product is intended for research and analytical applications. Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins .
    Methyl linoleate (Standard)
  • HY-W050154R
    Kojic acid (Standard)

    		Parasite Tyrosinase NF-κB CDK Infection Inflammation/Immunology Cancer
    Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields .
    Kojic acid (Standard)
  • HY-N10802
    6-O-Isobutyrylbritannilactone

    		ERK Akt PI3K Epigenetic Reader Domain Cancer
    6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models .
    6-O-Isobutyrylbritannilactone

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