2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Isolindleyin

Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a Kd of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities.

For research use only. We do not sell to patients.

Isolindleyin Chemical Structure

Isolindleyin Chemical Structure

CAS No. : 87075-18-1

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Based on 1 publication(s) in Google Scholar

Isolindleyin Related Antibodies

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Description

Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a Kd of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities[1].

IC50 & Target

Kd: 54.8 μM (human tyrosinase)[1]
In Vitro

Isolindley (1-500 μM; 7 days) suppresses melanin synthesis in human epidermal melanocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isolindleyin Related Antibodies
Molecular Weight

478.45

Formula

C23H26O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(CCC(C=C1)=CC=C1O[C@H]2[C@@H]([C@H]([C@H](O)[C@@H](CO)O2)O)OC(C3=CC(O)=C(O)C(O)=C3)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (104.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0901 mL 10.4504 mL 20.9008 mL
5 mM 0.4180 mL 2.0901 mL 4.1802 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0901 mL 10.4504 mL 20.9008 mL 52.2521 mL
5 mM 0.4180 mL 2.0901 mL 4.1802 mL 10.4504 mL
10 mM 0.2090 mL 1.0450 mL 2.0901 mL 5.2252 mL
15 mM 0.1393 mL 0.6967 mL 1.3934 mL 3.4835 mL
20 mM 0.1045 mL 0.5225 mL 1.0450 mL 2.6126 mL
25 mM 0.0836 mL 0.4180 mL 0.8360 mL 2.0901 mL
30 mM 0.0697 mL 0.3483 mL 0.6967 mL 1.7417 mL
40 mM 0.0523 mL 0.2613 mL 0.5225 mL 1.3063 mL
50 mM 0.0418 mL 0.2090 mL 0.4180 mL 1.0450 mL
60 mM 0.0348 mL 0.1742 mL 0.3483 mL 0.8709 mL
80 mM 0.0261 mL 0.1306 mL 0.2613 mL 0.6532 mL
100 mM 0.0209 mL 0.1045 mL 0.2090 mL 0.5225 mL
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Isolindleyin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isolindleyin87075-18-1Tyrosinasebutyrophenoneanti-inflammatoryanalgesicanti-melanogenicInhibitorinhibitorinhibit

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