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Results for "

antinecroptotic activity

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169074
    Thalidomide-N-methylpiperazine

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model .
    Thalidomide-N-methylpiperazine
  • HY-157963
    RIPK1-IN-23

    		RIP kinase Necroptosis Inflammation/Immunology Cancer
    RIPK1-IN-23 (compound 19) is a RIPK1 inhibitor with potent anti-necroptotic effects in HT-29 cells (EC50 of 1.7 nM). RIPK1-IN-23 shows anti-inflammatory activities .
    RIPK1-IN-23
  • HY-149052
    SZM-1209

    		RIP kinase Mixed Lineage Kinase Necroptosis Inflammation/Immunology
    SZM-1209 is an orally active, potent and specific RIPK1 inhibitor, with a Kd of 85 nM. SZM-1209 exhibits high anti-necroptotic activity (EC50=22.4 ± 8.1 nM). SZM-1209 shows anti-SIRS (systemic inflammatory response syndrome), and anti-ALI (acute lung injury) effects .
    SZM-1209
  • HY-169072
    PROTAC MLKL Degrader-2

    		PROTACs Mixed Lineage Kinase Cancer
    PROTAC MLKL Degrader-2 is a PROTAC targeting MLKL (Mixed Lineage Kinase). PROTAC MLKL Degrader-2 consists of PROTAC target protein ligand PROTAC MLKL Degrader-2 (HY-169072), E3 ligase ligand Thalidomide (HY-14658) and PROTAC Linker N-Methylpiperazine (HY-78871), of which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-N-methylpiperazine (HY-169074). PROTAC MLKL Degrader-2 exhibits antinecroptotic activity on human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model .
    PROTAC MLKL Degrader-2

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