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Results for "

cAMP/PKA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PKA (63) Akt (2) AMPK (2) Antibiotic (1) Apoptosis (5) Bacterial (1) Calcium Channel (1) CRFR (1) Endogenous Metabolite (2) Epigenetic Reader Domain (1) ERK (2) Fluorescent Dye (1) Fungal (1) Kisspeptin Receptor (2) Myosin (3) NF-κB (1) p38 MAPK (2) Parasite (1) Phosphodiesterase (PDE) (11) PKC (8) PKG (1) Potassium Channel (1) PPAR (2) Prostaglandin Receptor (1) Ras (5) ROCK (3)
By Research Areas:	Cancer (20) Cardiovascular Disease (4) Endocrinology (5) Infection (2) Inflammation/Immunology (11) Metabolic Disease (18) Neurological Disease (16)
Oligonucleotides:	Antisense Oligonucleotides (2)

Inhibitors & Agonists

Screening Libraries

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Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: PKA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100530C

Sp-cAMPS sodium salt	PKA Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease
Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K_i of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC₅₀ of 40 μM .

HY-134298

8-CPT-6-Phe-cAMP 8-(4-Chlorophenylthio)-N6-phenyl-cAMP	PKA	Others
8-CPT-6-Phe-cAMP is an analogue of signal molecule cAMP and a potent protein kinase A (PKA) activator .

HY-100530B

Sp-cAMPS	PKA Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease
Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K_i of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC₅₀ of 40 μM .

HY-110005

Sp-cAMPS triethylamine	PKA Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease
Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K_i of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC₅₀ of 40 μM .

HY-131777

2-Cl-cAMP	Others	Others
2-Cl-cAMP is an analog of cAMP and a potent stimulator of cAMP-dependent protein kinases such as PKA type I and II. 2-Cl-cAMP can be used as starting material for cyclic nucleotides .

HY-B0764B

Bucladesine Dibutyryl cAMP; DBcAMP	PKA	Neurological Disease
Bucladesine (DBcAMP) is a membrane permeable selective activator that activates cyclic adenosine phosphate dependent protein kinase A (PKA). The main regulatory mechanism of Bucladesine involves the cAMP/PKA signaling pathway. When Bucladesine activates *PKA, it can promote a variety of cellular processes, including neurodevelopment, growth and plasticity. In particular, the cAMP/PKA* signaling pathway plays a key role in the expression of long-term enhancement (LTP) and long-term inhibition (LTD), as well as in the formation of long-term memory in the hippocampus. Bucladesine can be used to study memory formation and neuroplasticity .

HY-137530

8-MA-cAMP 8-Methylamino-cAMP	PKA	Others
8-MA-cAMP (8-Methylamino-cAMP) is a cyclic AMP analog that acts as a site-selective *PKA* agonist with similar affinity for the B site of type I and type II protein kinase A. 8-MA-cAMP is used in conjunction with priming analogs that show site A preference, such as 8-piperidinyl cAMP, to achieve selective stimulation of type I .

HY-134263

*8-Br-cAMP-AM*	PKA Ras	Cardiovascular Disease
8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury .

HY-137381

6-Bnz-cAMP N6-Benzoyl-cAMP	Potassium Channel	Others
6-Bnz-cAMP (N6-Benzoyl-cAMP), a derivative of cyclic adenosine monophosphate (cAMP), is a potent inhibitor of the bTREK-1 potassium channel. 6-Bnz-cAMP can strongly inhibit the bTREK-1 potassium channel through a protein kinase A (PKA) independent mechanism. 6-Bnz-cAMP can be used to explore potential signal transduction proteins in the cAMP signaling pathway .

HY-134308

*8-NBD-cAMP* sodium**	Fluorescent Dye	Others
8-NBD-cAMP sodium is a fluorescently labeled cyclic adenosine phosphate (cAMP) analogue. 8-NBD-cAMP sodium retains a similar biological activity to cAMP, regulating their activity by binding to specific proteins such as EPACs or *PKA. 8-NBD-cAMP* sodium can be used in fluorescent competitive binding experiments to evaluate the binding affinity of newly synthesized EPAC1 agonists to EPAC1 proteins .

HY-120994

Rp-8-CPT-cAMPS sodium	PKA	Neurological Disease Inflammation/Immunology
Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI .

HY-120994A

Rp-8-CPT-cAMPS	PKA	Neurological Disease Inflammation/Immunology
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI .

HY-134302

8-HA-cAMP 8-Hexylamino-cAMP	PKA	Others
8-HA-cAMP is a membrane-permeable cAMP analogue and an activator of cAMP-dependent protein kinase and PKA I. 8-HA-cAMP exerts metabolic stability towards mammalian cyclic nucleotide-responsive phosphodiesterases .

HY-108047

MK-0873	Phosphodiesterase (PDE)	Metabolic Disease Inflammation/Immunology
MK-0873 is a selective phosphodiesterase-4 (PDE4) inhibitor. MK-0873 increases intracellular levels of cyclic adenosine phosphate (cAMP) by inhibiting the activity of the PDE4 enzyme and subsequently activates protein kinase A (PKA). Activated PKA inhibits the activity of inflammatory cells and leads to direct relaxation of airway smooth muscle. MK-0873 can be used in studies of chronic obstructive pulmonary disease (COPD) .

HY-137640B

Rp-8-Br-cAMPS	PKA	Inflammation/Immunology Cancer
Rp-8-Br-cAMPS is an analog of cAMP and an inhibitor of *PKA. Rp-8-Br-cAMPS* occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS also inhibits insulin secretion .

HY-137640C

Rp-8-Br-cAMPS sodium	PKA	Inflammation/Immunology Cancer
Rp-8-Br-cAMPS sodium is an analog of cAMP and an inhibitor of *PKA. Rp-8-Br-cAMPS* sodium occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS sodium can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS sodium also inhibits insulin secretion .

HY-103322

*6-Bnz-cAMP* sodium salt**	PKA	Cancer
6-Bnz-cAMP sodium salt is a cell-permeable cAMP analog. 6-Bnz-cAMP selectively activates cAMP-dependent PKA but not Epac signaling pathways .

HY-123396

8-Chloro-cAMP	PKA	Cancer
8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent *PKA* activity. 8-Chloro-cAMP has anticancer activity .

HY-123396A

*8-Chloro-cAMP* sodium**	PKA	Cancer
8-Chloro-cAMP sodium is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent *PKA* activity. 8-Chloro-cAMP sodium has anticancer activity .

HY-137624

Sp-cAMPS-AM	PKA	Others
Sp-cAMPS-AM is an analog of cAMP. Sp-cAMPS-AM acts as the inducer of *PKA* activation and CREB phosphorylation, through entrance into the cell and release of its parent polar structure Sp-cAMPS .

HY-120994B

Sp-8-CPT-cAMPS	PKA	Neurological Disease Inflammation/Immunology
Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent *protein kinas A (PKA* I and PKA II)*. Sp-8-CPT-cAMPS* selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold .

HY-134340

8-pMeOPT-2'-O-Me-cAMP 8-(4-Methoxyphenylthio)-2'-O-Me-cAMP	Ras Others	Others
8-pMeOPT-2'-O-Me-cAMP is an analogue of the signal molecule cAMP and a potent stimulator of exchange factors activated by cAMP (Epac), while it doesn't activate PKA as cAMP does .

HY-100530A

Rp-cAMPS	PKA	Neurological Disease
Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases .

HY-100530D

Rp-cAMPS sodium salt 3 Publications Verification	PKA	Neurological Disease
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases .

HY-P0248

Kemptide	PKA	Metabolic Disease
Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA).

HY-100530

Rp-cAMPS triethylammonium salt	PKA	Neurological Disease
Rp-cAMPS triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases .

HY-P1290A

PKA Inhibitor Fragment (6-22) amide TFA 2 Publications Verification PKI-(6-22)-amide TFA	PKA	Neurological Disease
PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a K_i of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse antinociceptive tolerance in mice .

HY-B0764A

Bucladesine calcium Maximum Cited Publications 28 Publications Verification Dibutyryl cAMP calcium salt; DBcAMP calcium salt	PKA Phosphodiesterase (PDE) Apoptosis	Others
Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.

HY-P1290

PKA Inhibitor Fragment (6-22) amide PKI-(6-22)-amide	PKA	Neurological Disease
PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a K_i of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice .

HY-131842

6-Bn-cAMP N6-Benzyladenosine-3',5'-cyclic monophosphate	PKA	Cancer
6-Bn-cAMP is a site-selective activator of **cAMP-dependent protein kinase (PKA)** which does not activate Epac. 6-Bn-cAMP increases hydrolytic stability against PDE, esterases, amidases and considerably higher membrane permeability compared to cAMP .

HY-P3930

PKI (5-24),amide IP20-amide	PKA	Neurological Disease
PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependent protein kinase. PKI (5-24),amide is a potent cAMP-dependent protein kinase (PKA) (PKA) inhibitor with a K_i of 2.3 nM .

HY-12306

*8-Bromo-cAMP* sodium salt** 20+ Cited Publications 8-Br-cAMP sodium salt	PKA Apoptosis	Cancer
8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells .

HY-12306A

8-Bromo-cAMP 20+ Cited Publications 8-Br-cAMP	PKA Apoptosis	Cancer
8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells .

HY-134325

8-OH-cAMP 8-Hydroxy-cAMP	PKA	Cardiovascular Disease Metabolic Disease
8-OH-cAMP (8-Hydroxy-cAMP) is a polar, membrane-impermeable cyclic adenosine monophosphate analog that is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. As a polar *PKA* agonist, 8-OH-cAMP is used to study the role of cAMP in the development and progression of cardiovascular and metabolic diseases .

HY-P0291

Kemptide Phospho-Ser5	PKA	Others
Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).

HY-P3770

Phosphate acceptor peptide	PKC	Others
Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak PKC inhibitor .

HY-134389

6-Phe-cAMP N6-Phenyladenosine-3',5'-cyclic monophosphate	PKA	Cancer
6-Phe-cAMP is a site-selective and highly membrane-permeant activator of protein kinase A (PKA), with a strong preference for site A of both isozymes. 6-Phe-cAMP can undergo phosphorothioate modification .

HY-137640

Sp-8-Br-cAMPS	PKA	Others
Sp-8-Br-cAMPS is an analog of cAMP(HY-B1511). Sp-8-Br-cAMPS is an agonist for *cAMP, which performs a protein kinase A (PKA)* activating activity with EC₅₀ of 360 nM. Sp-8-Br-cAMPS inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve .

HY-B0764

Bucladesine sodium Maximum Cited Publications 28 Publications Verification Dibutyryl cAMP sodium salt; DBcAMP sodium salt	PKA Phosphodiesterase (PDE)	Inflammation/Immunology
Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective *PKA* activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing .

HY-137640A

Sp-8-Br-cAMPS sodium	PKA	Inflammation/Immunology
Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC₅₀ of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve .

HY-134264

8-Br-2'-O-Me-cAMP	Ras Others	Cardiovascular Disease Neurological Disease
8-Br-2'-O-Me-cAMP is an analogue of the signal molecule cyclic AMP (cAMP). 8-Br-2'-O-Me-cAMP is an agonist of exchange factors activated by cAMP (Epac), while it doesn't activate PKA as cAMP do. 8-Br-2'-O-Me-cAMP can be used in cardiovascular disease research .

HY-B1898

Metadoxine	PKA	Metabolic Disease
Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein *(PKA-CREB)* pathway.

HY-P1595

CREBtide	PKA	Metabolic Disease
CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a *PKA* substrate.

HY-134332

8-pCPT-5'-AMP 8-(4-Chlorophenylthio)-5'-AMP	PKA PKG	Others
8-pCPT-5'-AMP is an analogue of 5'-AMP and a lipophilic activator of PKA, PKG and Epac (exchange protein activated by cAMP) .

HY-B0764R

Bucladesine sodium (Standard)	PKA Phosphodiesterase (PDE)	Inflammation/Immunology
Bucladesine (sodium) (Standard) is the analytical standard of Bucladesine (sodium). This product is intended for research and analytical applications. Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective *PKA* activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing .

HY-137646

Sp-2-Cl-cAMPS	PKA Parasite	Infection
Sp-2-Cl-cAMPS is an agonist for *PKA* with improved membrane permeability and stability to phosphodiesterase. Sp-2-Cl-cAMPS exhibits antimalarial activity, and inhibits the proliferation of Plasmodium falciparum with an EC₅₀ of 4 μM. Sp-2-Cl-cAMPS binds to purified P. falciparum PfPKAr (regulatory subunit of PfPKA) with a K_i of 1.3 µM .

HY-136172

ESI-08 1 Publications Verification	Ras	Cardiovascular Disease Metabolic Disease Cancer
ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC₅₀ of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation .

HY-P1291

PKI 14-22 amide,myristoylated 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated is a potent **cAMP-dependent PKA** inhibitor. PKI 14-22 amide,myristoylated reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P1595A

CREBtide TFA	PKA	Metabolic Disease
CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a *PKA* substrate .

HY-P1291A

PKI 14-22 amide,myristoylated TFA 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated TFA is a potent **cAMP-dependent PKA** inhibitor. PKI 14-22 amide,myristoylated TFA reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

Cat. No.	Product Name

HY-L165

Dopamine Receptor Compound Library

203 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 203 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Cat. No.	Product Name	Target	Research Area

HY-P0248

Kemptide	PKA	Metabolic Disease
Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA).

HY-P1290A

PKA Inhibitor Fragment (6-22) amide TFA 2 Publications Verification PKI-(6-22)-amide TFA	PKA	Neurological Disease
PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a K_i of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse antinociceptive tolerance in mice .

HY-P1595

CREBtide	PKA	Metabolic Disease
CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a *PKA* substrate.

HY-P1291

PKI 14-22 amide,myristoylated 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated is a potent **cAMP-dependent PKA** inhibitor. PKI 14-22 amide,myristoylated reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P1595A

CREBtide TFA	PKA	Metabolic Disease
CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a *PKA* substrate .

HY-P1291A

PKI 14-22 amide,myristoylated TFA 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated TFA is a potent **cAMP-dependent PKA** inhibitor. PKI 14-22 amide,myristoylated TFA reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P1290

PKA Inhibitor Fragment (6-22) amide PKI-(6-22)-amide	PKA	Neurological Disease
PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a K_i of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice .

HY-P3930

PKI (5-24),amide IP20-amide	PKA	Neurological Disease
PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependent protein kinase. PKI (5-24),amide is a potent cAMP-dependent protein kinase (PKA) (PKA) inhibitor with a K_i of 2.3 nM .

HY-P0291

Kemptide Phospho-Ser5	PKA	Others
Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).

HY-P3770

Phosphate acceptor peptide	PKC	Others
Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak PKC inhibitor .

HY-P1597

Malantide 1 Publications Verification	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by **cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a K_m** of 16 μM .

HY-P1597A

Malantide TFA	PKA PKC	Cancer
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by **cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a K_m** of 16 μM .

HY-P10336

Serpinin	Peptides	Neurological Disease Endocrinology
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function . Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects .

HY-P0222

PKI(5-24) 3 Publications Verification	PKA	Others
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of *PKA* (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-P0222A

PKI(5-24) TFA	PKA	Others
PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of *PKA* (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-P10256

Kiss2 peptide	Kisspeptin Receptor PKA PKC	Endocrinology
Kiss2 peptide is a positive regulator of reproduction. Kiss2 peptide binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc) .

HY-P10256A

Kiss2 peptide acetate	Kisspeptin Receptor PKA PKC	Endocrinology
Kiss2 peptide acetate is the acetate form of Kiss2 pepride (HY-P10256). Kiss2 peptide acetate is a positive regulator of reproduction. Kiss2 peptide acetate binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc) .

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .

Species:	Human (3) Canine (1)
Tag:	His (1) Tag Free (2) GST (1)
Source:	Sf9 insect cells (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P701068

	PKA/PRKACA Protein, Canine (His) cAMP-dependent protein; PRKACA; PKA C-alpha; PKACA; PKA C alpha; PPNAD4	Canine	E. coli
	PKA/PRKACA Protein, Canine (His) is the recombinant canine-derived PKA/PRKACA protein, expressed by E. coli , with N-His labeled tag. The total length of PKA/PRKACA Protein, Canine (His) is 349 a.a., with molecular weight of 41.51 kDa.

HY-P701753

	PKACα Protein, Human (Sf9, GST) PRKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha	Human	Sf9 insect cells
	PKACα protein is a key kinase that phosphorylates a variety of substrates, including CDC25B, ABL1, NFKB1, and VASP, affecting a variety of cellular processes, such as cell cycle progression, platelet regulation, and adipogenic differentiation. It also negatively regulates mTORC1 through RPTOR phosphorylation, thereby modulating signaling networks. PKACα Protein, Human (Sf9, GST) is the recombinant human-derived PKACα protein, expressed by Sf9 insect cells , with GST tagged. The total length of PKACα Protein, Human (Sf9, GST) is 350 a.a., .

HY-P702638

	PRKACG Protein, Human (sf9) PRKACG; protein kinase, cAMP-dependent, catalytic, gamma; cAMP-dependent protein kinase catalytic subunit gamma; PKACg; PKA C-gamma; serine(threonine) protein kinase; KAPG	Human	Sf9 insect cells
	PRKACG Protein, Human (sf9) is the recombinant human-derived PRKACG, expressed by Sf9 insect cells , with tag Free labeled tag. ,

HY-P702637

	PRKACB Protein, Human (sf9) PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; PKACB; MGC9320; MGC41879; DKFZp781I2452	Human	Sf9 insect cells
	PRKACB Protein, Human (sf9) is the recombinant human-derived PRKACB, expressed by Sf9 insect cells , with tag Free labeled tag. ,

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81127

	PKA alpha + beta Antibody PRKACA/PRKACB; PRKACA + PRKACB; PKA alpha + beta; PKA alpha; PKA beta; cAMP dependent protein kinase alpha catalytic subunit; cAMP dependent protein kinase beta catalytic subunit; cAMP dependent protein kinase catalytic subunit alpha; cAMP dependent protein kinase catalytic subunit beta; DKFZp781I2452; MGC102831; MGC41879; MGC48865; MGC9320; PKA C alpha; PKA C beta; PKACA; PKACB; PRKACA; PRKACB; Protein kinase A catalytic subunit alpha; Protein kinase A catalytic subunit; Protein kinase A catalytic subunit beta; Protein kinase cAMP dependent catalytic alpha; Protein kinase cAMP dependent catalytic beta; cAMP dependent protein kinase catalytic subunit alpha isoform 1; cAMP-dependent protein kinase catalytic subunit alpha; KAPCA_HUMAN; KAPCB_HUMAN; PKA C alpha; PKA C-alpha; PKACA; PRKACA; Protein kinase A catalytic subunit; Protein kinase cAMP dependent catalytic alpha.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
	PKA alpha + beta Antibody is an unconjugated, approximately 40 kDa, rabbit-derived, anti-PKA alpha + beta polyclonal antibody. PKA alpha + beta Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat background without labeling.

HY-P80847

	Phospho-PKA RII alpha (Ser99) Antibody 1 Publications Verification PRKAR2A; PKR2; PRKAR2; cAMP-dependent protein kinase type II-alpha regulatory subunit	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Pig
	Phospho-PKA RII alpha (Ser99) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 46 kDa, targeting to Phospho-PKA RII alpha (Ser99). It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat, Pig.

HY-P81981

	PKA C gamma Antibody (YA1726) PRKACG; cAMP-dependent protein kinase catalytic subunit gamma; PKA C-gamma	WB, IP	Human, Mouse, Rat
	PKA C gamma Antibody (YA1726) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1726), targeting PKA C gamma, with a predicted molecular weight of 40 kDa (observed band size: 40 kDa). PKA C gamma Antibody (YA1726) can be used for WB, IP experiment in human, mouse, rat background.

HY-P82006

	PKA RI alpha Antibody (YA1751) PRKAR1A; PKR1; PRKAR1; TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; Tissue-specific extinguisher 1; TSE1	WB	Human, Rat
	PKA RI alpha Antibody (YA1751) is a biotin-conjugated non-conjugated IgG antibody, targeting PKA RI alpha, with a predicted molecular weight of 43 kDa (observed band size: 43 kDa). PKA RI alpha Antibody (YA1751) can be used for WB experiment in human, rat background.

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Free Sample	Yes No
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Cat. No.	Product Name		Classification

HY-148827A

GEM-231 sodium HYBO-165 sodium		Antisense Oligonucleotides
GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the *PKA-I* (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

HY-148827

GEM-231 HYBO-165		Antisense Oligonucleotides
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the *PKA-I* (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

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