Sp-8-Br-cAMPS sodium 

Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC₅₀ of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve^[1][2].

Sp-8-Br-cAMPS sodium (0-100 nM) inhibits phagocytosis of X. nematophila and B. subtilis without affecting the number of bacteria per haemocyte type^[1].
Sp-8-Br-cAMPS sodium (0-1000 μM) inhibits Staphylococcal enterotoxin B (SEB)-induced T-cell activation and expressions of cytokines IFN-γ, TNF-α, IL-2, and IL-4 in a dose-dependent manner through activation of PKA^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sp-8-Br-cAMPS sodium (50 nM) inhibits protein release from haemocytes, inhibits the bacterial removal from haemolymph without affecting haemocyte viability in G. mellonella larvae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.15

C₁₀H₁₀BrN₅NaO₅PS

1573115-90-8

NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(S[Na])=O)O3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Brooks CL, et al., Protein kinase A affects Galleria mellonella (Insecta: Lepidoptera) larval haemocyte non-self responses. Immunol Cell Biol. 2005 Apr;83(2):150-9.  [Content Brief]

  [2]. Aandahl EM, et al., Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol. 2002 Jul 15;169(2):802-8.  [Content Brief]