Bucladesine (Synonyms: Dibutyryl cAMP; DBcAMP)

Cat. No.: HY-B0764B: FAQs
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Bucladesine (DBcAMP) is a membrane permeable selective activator that activates cyclic adenosine phosphate dependent protein kinase A (PKA). The main regulatory mechanism of Bucladesine involves the cAMP/PKA signaling pathway. When Bucladesine activates PKA, it can promote a variety of cellular processes, including neurodevelopment, growth and plasticity. In particular, the cAMP/PKA signaling pathway plays a key role in the expression of long-term enhancement (LTP) and long-term inhibition (LTD), as well as in the formation of long-term memory in the hippocampus. Bucladesine can be used to study memory formation and neuroplasticity.

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Bucladesine Chemical Structure

CAS No. : 362-74-3

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Other In-stock Forms of Bucladesine:

Bucladesine sodium Bucladesine calcium

Other Forms of Bucladesine:

Bucladesine sodium In-stock
Bucladesine calcium In-stock

28 Publications Citing Use of MCE Bucladesine

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	28.9 μM Compound: dbcAMP	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA	[PMID: 11000020]

Molecular Weight

469.39

Formula

C₁₈H₂₄N₅O₈P

CAS No.

362-74-3

SMILES

O=C(CCC)O[C@H]1[C@H](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[C@@](CO4)([H])[C@@]1([H])OP4(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sharifzadeh M, et al. Post-training intrahippocampal infusion of nicotine–bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats[J]. European journal of pharmacology, 2007, 562(3): 212-220. [Content Brief]

Bucladesine Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bucladesine362-74-3Dibutyryl cAMP DBcAMPPKAProtein kinase AcAMPNeuroplasticityMemory FormationNeurobiologyInhibitorinhibitorinhibit

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