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Results for "

complement factor B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Complement System (12)
By Research Areas:	Inflammation/Immunology (11) Metabolic Disease (2)
Oligonucleotides:	Aptamers (1) Antisense Oligonucleotides (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Complement System

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148370A

IONIS-FB-LRx sodium RG6299 sodium	Complement System	Others
IONIS-FB-LRx sodium is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). IONIS-FB-LRx sodium effectively reduces circulating levels of CFB, and can be used for geographic atrophy (GA) research .

HY-127105

Iptacopan 5+ Cited Publications LNP023	Complement System	Metabolic Disease Inflammation/Immunology
Iptacopan (LNP023) is a first-in-class, orally bioavailable, highly potent and highly selective factor B inhibitor with an IC₅₀ value of 10 nM. Iptacopan shows direct, reversible, and high-affinity binding to human factor B with a K_D of 7.9 nM. Iptacopan targets the underlying cause of complement 3 glomerulopathy (C3G) .

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

HY-147080

Avacincaptad pegol sodium ARC1905	Complement System	Others
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system. Avacincaptad pegol sodium treats Geographic atrophy (GA) mice .

HY-148370

IONIS-FB-LRx RG6299	Complement System	Others
IONIS-FB-LRx is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). IONIS-FB-LRx effectively reduces circulating levels of CFB. IONIS-FB-LRx can be used for geographic atrophy (GA) research .

HY-147605

Factor B-IN-3	Complement System	Inflammation/Immunology
Factor B-IN-3 (Example 3 target compound) is a potent complement factor B inhibitor. Factor B-IN-3 can be used for the research of diseases related to inflammation and immunity .

HY-147606

Factor B-IN-4	Complement System	Inflammation/Immunology
Factor B-IN-4 (Example 13 target compound) is a potent complement factor B inhibitor, with an IC₅₀ of 1 μM. Factor B-IN-4 can be used for the research of diseases related to inflammation and immunity .

HY-147607

Lanoracopan	Complement System	Inflammation/Immunology
Factor B-IN-5 (Example 5 target compound) is a potent complement factor B inhibitor, with an IC₅₀ of 1.2 μM. Factor B-IN-5 can be used for the research of diseases related to inflammation and immunity .

HY-147604

Factor B-IN-2	Complement System	Inflammation/Immunology
Factor B-IN-2 (Example 1 target compound) is a potent complement factor B inhibitor, with an IC₅₀ of 1.5 μM. Factor B-IN-2 can be used for the research of diseases related to inflammation and immunity .

HY-P990378

*Anti-Complement* Factor P/Properdin Antibody**	Complement System	Inflammation/Immunology
Anti-Complement Factor P/Properdin Antibody is a humanized antibody expressed in CHO, targeting Complement Factor P/Properdin. Anti-Complement Factor P/Properdin Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Complement Factor P/Properdin Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-122700

Factor D inhibitor 6	Complement System	Inflammation/Immunology
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC₅₀ of 30 nM and a K_d of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .

HY-127105A

Iptacopan hydrochloride 5+ Cited Publications LNP023 hydrochloride	Complement System	Metabolic Disease Inflammation/Immunology
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a K_D of 7.9 nM. LNP023 inhibits factor B with an IC₅₀ value of 10 nM .

Cat. No.	Product Name	Type

HY-NP004

Cobra Venom Factor CVF	Native Proteins
Cobra venom factor (CVF) is the complement-activating protein from cobra venom. CVF is a three-chain protein that functionally resembles C3b, the activated form of complement component C3. Cobra Venom Factor can be used for the research of the functions of complement in host defense and immune response as well as in the pathogenesis of diseases .

Cat. No.	Product Name	Target	Research Area

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

HY-P990377

*Anti-Complement* Factor B Antibody**	Inhibitory Antibodies	Inflammation/Immunology

HY-P990378

*Anti-Complement* Factor P/Properdin Antibody**	Complement System	Inflammation/Immunology
Anti-Complement Factor P/Properdin Antibody is a humanized antibody expressed in CHO, targeting Complement Factor P/Properdin. Anti-Complement Factor P/Properdin Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Complement Factor P/Properdin Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Recombinant Proteins Recommended:

Complement Factor B

Species:	Human (2) Mouse (2)
Tag:	His (4)
Source:	HEK293 (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7813

	Complement Factor B/CFB Protein, Human (HEK293, His) rHucomplement factor B, His; complement factor B; C3/C5 Convertase; Glycine-Rich Beta Glycoprotein; GBG; PBF2; Properdin factor B; CFB; BF; BFD	Human	HEK293
	Complement Factor B/CFB Protein, Human (HEK293, His) is the recombinant human-derived Complement Factor B/CFB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Complement Factor B/CFB Protein, Human (HEK293, His) is 739 a.a., with molecular weight of 90-120 kDa.

HY-P72137

	Complement Factor B/CFB Protein, Mouse (His) 1 Publications Verification Cfb; Bf; H2-Bfcomplement factor B; EC 3.4.21.47; C3/C5 convertase; complement factor B Ba fragment; complement factor B Bb fragment	Mouse	E. coli
	CFB is an important component of the alternative pathway of the complement system and is cleaved by factor D, producing two fragments: Ba and Bb. The Bb fragment is characterized as a serine protease and subsequently forms a complex with complement factor 3b, ultimately producing a C3 or C5 convertase. Complement Factor B/CFB Protein, Mouse (His) is the recombinant mouse-derived CFB protein, expressed by E. coli , with N-6*His labeled tag. The total length of Complement Factor B/CFB Protein, Mouse (His) is 739 a.a., with molecular weight of ~87 kDa.

HY-P703770

	Complement factor I Protein, Mouse (HEK293, His) complement factor I; C3B/C4B inactivator; Cfi	Mouse	HEK293

HY-P703793

	Complement factor I Protein, Human (HEK293, His) complement factor I; C3B/C4B inactivator; CFI	Human	HEK293

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HY-P83239

	Complement factor B Antibody (YA2984) C3/C5 convertase; complement factor B; PBF2; Properdin factor B	WB	Human
	Complement factor B Antibody (YA2984) is a non-conjugated IgG antibody, targeting Complement factor B, with a predicted molecular weight of 86 kDa (observed band size: 100 kDa). Complement factor B Antibody (YA2984) can be used for WB experiment in human background.

HY-P83616

	Factor H Antibody (YA3361) AHUS1; AMBP1; ARMD4; ARMS1; beta1H; CFH; CFHL3; complement factor H; isoform b; factor H; factor H like 1; FHL1; HF1; HF2; HUS	WB, ICC/IF	Human
	Factor H Antibody (YA3361) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3361), targeting Factor H, with a predicted molecular weight of 139 kDa (observed band size: 180 kDa). Factor H Antibody (YA3361) can be used for WB, ICC/IF experiment in human background.

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Cat. No.	Product Name		Classification

HY-148370A

IONIS-FB-LRx sodium RG6299 sodium		Antisense Oligonucleotides
IONIS-FB-LRx sodium is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). IONIS-FB-LRx sodium effectively reduces circulating levels of CFB, and can be used for geographic atrophy (GA) research .

HY-147080

Avacincaptad pegol sodium ARC1905		Aptamers
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system. Avacincaptad pegol sodium treats Geographic atrophy (GA) mice .

HY-148370

IONIS-FB-LRx RG6299		Antisense Oligonucleotides
IONIS-FB-LRx is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). IONIS-FB-LRx effectively reduces circulating levels of CFB. IONIS-FB-LRx can be used for geographic atrophy (GA) research .

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