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Results for "

costimulatory receptor

" in MedChemExpress (MCE) Product Catalog:

2

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Biochemical Assay Reagents

5

Inhibitory Antibodies

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Antibodies

13

Oligonucleotides

Cat. No. Product Name Target Research Area
  • HY-P99570

    GBR-830

    Inhibitory Antibodies Inflammation/Immunology
    Telazorlimab (GBR-830) is a humanized monoclonal antibody against OX40 costimulatory receptor on activated T cells. Telazorlimab can be used for the research of autoimmune diseases .
  • HY-P99056

    PF 05082566

    TNF Receptor Inflammation/Immunology Cancer
    Utomilumab (PF 05082566) is a fully human IgG2 mAb agonist of the T-cell costimulatory receptor 4-1BB/CD137. Utomilumab can be used for the research of relapsed/refractory follicular lymphoma (FL) and other CD20 + non-Hodgkin lymphomas (NHL) .
  • HY-P99431

    Alomfilimab; SAR 445256

    Inhibitory Antibodies Inflammation/Immunology Cancer
    KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOS high cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8 + TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response .
  • HY-P99159

    Inhibitory Antibodies Cancer
    Ivuxolimab is an OX40 (also known as CD134; TNFRSF4) agonist monoclonal antibody. OX40 is a costimulatory receptor expressed on activated CD4 + and CD8 + T cells. Ivuxolimab shows antitumor activity, with potential immunostimulatory activity .
  • HY-P990680

    Inhibitory Antibodies Inflammation/Immunology
    Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is a rat-derived IgG2a monoclonal antibody targeting mouse CD40. CD40 is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 can act as a co-stimulatory molecule to activate B cells, dendritic cells, monocytes, and other APCs, promoting anti-tumor T cell responses.

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