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Results for "

cullin 3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) E1/E2/E3 Enzyme (3) TGF-beta/Smad (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3)

5

Inhibitors & Agonists

2

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

DI-591	E1/E2/E3 Enzyme	Cancer
DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with K_i values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of *cullin 3* but has no or minimal effect on neddylation of other cullin family members .

DI-1859	E1/E2/E3 Enzyme	Cardiovascular Disease
DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage .

NAE-IN-2	Apoptosis	Cancer
NAE-IN-2 (compound III-26) is N2–(1-benzylpiperidin-4-yl)quinazoline-2,4-diamine derivative, and inhibits Cullin1 and Cullin3. NAE-IN-2 inhibits migration and induces cell apoptosis of gastric cancer cells .

DI-404	E1/E2/E3 Enzyme	Cardiovascular Disease
DI-404 is a potent inhibitor of DCN1 with a KK_d value of 6.7 nM. DI-404 selectively inhibits neddylation of cullin 3 in a dose-dependent manner .

DCN1-IN-2	TGF-beta/Smad	Cardiovascular Disease
DCN1-IN-2 is a DCN1 inhibitor with an IC₅₀ value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting *cullin 3* .

Species:	Human (2)
Tag:	His (1) Tag Free (1) Strep (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

	KLHL42 Protein, Human (Sf9) KLHL42; Kelch-like protein 42; cullin-3-binding protein 9; Ctb9; Kelch domain-containing protein 5	Human	Sf9 insect cells
	KLHL42 serves as a substrate-specific linker in the BCR E3 ubiquitin ligase complex and plays a critical role in mitotic progression and cytokinesis. The BCR(KLHL42) complex actively ubiquitinates and degrades KATNA1, contributing to the regulation of microtubule dynamics during mitosis. KLHL42 Protein, Human (Sf9) is the recombinant human-derived KLHL42 protein, expressed by Sf9 insect cells , with tag free. The total length of KLHL42 Protein, Human (Sf9) is 504 a.a., .

	KLHL42 Protein, Human (Sf9, His, Strep) KLHL42; Kelch-like protein 42; cullin-3-binding protein 9; Ctb9; Kelch domain-containing protein 5	Human	Sf9 insect cells
	KLHL42 serves as a substrate-specific linker in the BCR E3 ubiquitin ligase complex and plays a critical role in mitotic progression and cytokinesis. The BCR(KLHL42) complex actively ubiquitinates and degrades KATNA1, contributing to the regulation of microtubule dynamics during mitosis. KLHL42 Protein, Human (Sf9, His, Strep) is the recombinant human-derived KLHL42 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of KLHL42 Protein, Human (Sf9, His, Strep) is 504 a.a., .

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	Cullin 3 Antibody (YA2578) CUL3; KIAA0617; cullin-3; CUL-3	WB, IP	Human, Mouse, Rat
	Cullin 3 Antibody (YA2578) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2578), targeting Cullin 3, with a predicted molecular weight of 89 kDa (observed band size: 89 kDa). Cullin 3 Antibody (YA2578) can be used for WB, IP experiment in human, mouse, rat background.

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