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cyclin-D3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (5) Apoptosis (2) Casein Kinase (1) PI3K (1)
By Research Areas:	Cancer (10)

10

Inhibitors & Agonists

3

Natural
Products

3

Recombinant Proteins

2

Antibodies

Targets Recommended: Cyclin G-associated Kinase (GAK) CDK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Lerociclib 1 Publications Verification G1T38	CDK	Cancer
Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC₅₀s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.

Lerociclib dihydrochloride 1 Publications Verification G1T38 dihydrochloride	CDK	Cancer
Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC₅₀s of 1 nM and 2 nM for *CDK4/CyclinD1* and *CDK6/CyclinD3*, respectively.

Atirmociclib PF-07220060; CDK4/6-IN-6	CDK	Cancer
Atirmociclib (PF-07220060; example A94) is a potent CDK4/CDK6 inhibitor with a K_i of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively .

Eriocitrin 1 Publications Verification	Apoptosis	Cancer
Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

Araliadiol	Others	Cancer
Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC₅₀ value of 6.41 μg/mL .

CDK4/6-IN-5	CDK	Cancer
CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with K_is of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively . (from patent WO2019207463A1 example A93).

FD2056	PI3K	Cancer
FD2056 is a potent and orally active *PI3K* inhibitor. FD2056 inhibits PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ with IC₅₀s of 0.30, 0.80, 1.10, 0.42 nM. FD2056 also inhibits CDK2-CyclinA2 and CDK4-CyclinD3 with IC₅₀ of 115.95 and 2782.15 nM. FD2056 inhibits breast cancer cell proliferation with IC₅₀s of 1.06, 0.04, 1.40 μM for MDA-MB-231, MDA-MB-468, MCF-7 cells. FD2056 also induces cancer apoptosis and inhibits tumor growth .

Eriocitrin (Standard)	Apoptosis	Cancer
Eriocitrin (Standard) is the analytical standard of Eriocitrin. This product is intended for research and analytical applications. Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

Ulecaciclib	CDK	Cancer
Ulecaciclib is an orally activitive inhibitor of cyclin-dependent kinase (CDK), with K_i values of 0.62 μM (CDK2/Cyclin A), 0.2 nM (CDK4/Cyclin D1), 3 nM (CDK6/Cyclin D3), and 0.63 μM (CDK7/Cyclin H), respectively. Ulecaciclib can cross blood brain barrier and has good pharmacokinetic characteristics ^[3].

SR-1277	Casein Kinase	Cancer
SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC₅₀s of 49 nM and 260 nM, respectively. SR-1277 also inhibits *FLT3, CDK4/cyclin* D1, **CDK6/cyclin D3** and CDK9/cyclin K, with IC₅₀s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer .

Species:	Human (3)
Tag:	His (1) Tag Free (1) GST (2)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

	CCND3 Protein, Human (sf9, GST) G1/S-specific cyclin-D3; CCND3	Human	Sf9 insect cells

	CDK6-CCND3 Heterodimer Protein, Human (Sf9) CDK6; CCND3; cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D3	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND3 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK6-CCND3 Heterodimer protein, expressed by Sf9 insect cells , with tag free.

	CDK6-CCND3 Heterodimer Protein, Human (Sf9, GST, His) CDK6; CCND3; cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D3	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND3 Heterodimer Protein, Human (Sf9, GST, His) is a recombinant protein dimer complex containing human-derived CDK6-CCND3 Heterodimer protein, expressed by Sf9 insect cells , with N-10*His, N-GST labeled tag.

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	Cyclin D3 Antibody	WB, ICC/IF, FC	Human, Mouse
	Cyclin D3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 33 kDa, targeting to Cyclin D3. It can be used for WB,ICC/IF,FC assays with tag free, in the background of Human, Mouse.

	Cyclin D3/CCND3 Antibody (YA1201) CCND3 ; G1/S-specific cyclin-D3	IHC-P	Human
	Cyclin D3/CCND3 Antibody (YA1201) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1201), targeting Cyclin D3/CCND3. Cyclin D3/CCND3 Antibody (YA1201) can be used for IHC-P experiment in human background.

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