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Results for "

dynein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endogenous Metabolite (1) Hedgehog (2)
By Research Areas:	Cancer (3)

3

Inhibitors & Agonists

2

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Ciliobrevin D 3 Publications Verification	Hedgehog	Cancer
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits *dynein*-dependent microtubule gliding and ATPase activity in vitro .

Dynarrestin 2 Publications Verification	Hedgehog	Cancer
Dynarrestin is a aminothiazole inhibitor of *cytoplasmic dyneins* 1 and 2*. Dynarrestin rapidly and reversibly inhibits dynein* 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells .

AZD4877 hydrochloride	Endogenous Metabolite	Cancer
AZD4877 hydrochloride is a synthetic dynein inhibitor with potential anti-tumor activity. AZD4877 selectively inhibits the microtubule dynein KSP (also known as kinesin-5 or Eg5), which may lead to inhibition of mitotic spindle assembly. The action of AZD4877 may activate the spindle assembly checkpoint, leading to cell cycle arrest at the mitotic stage. AZD4877 may induce cell death in actively dividing tumor cells. AZD4877 may be less likely to cause peripheral neuropathy associated with microtubule-targeted compounds as it is not involved in post-mitotic processes. AZD4877 is essential for the formation of bipolar spindles and the proper segregation of sister chromosomes .

Species:	Human (2)
Tag:	His (2) SUMO (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	PIN/DYNLL1 Protein, Human (His) rHudynein light chain 1, cytoplasmic/DYNLL1, His; dynein Light Chain 1 Cytoplasmic; 8 kDa dynein Light Chain; DLC8; dynein Light Chain LC8-Type 1; Protein Inhibitor of Neuronal Nitric Oxide Synthase; PIN; DYNLL1; DLC1; DNCL1; DNCLC1; HDLC1	Human	E. coli
	PIN/DYNLL1 acts as a non-catalytic accessory component in the cytoplasmic dynein 1 complex, connecting dynein to cargos and adapter proteins for dynein modulation. It functions as a motor for retrograde vesicle movement along microtubules, potentially influencing cytoskeletal structure. PIN/DYNLL1 enhances ESR1 transactivation and aids ESR1 nuclear localization. PIN/DYNLL1 Protein, Human (His) is the recombinant human-derived PIN/DYNLL1 protein, expressed by E. coli, with N-6*His labeled tag. The total length of PIN/DYNLL1 Protein, Human (His) is 89 a.a., with molecular weight of ~14.0 kDa.

	DCTN1 Protein, Human (His-SUMO) 150kDa dynein associated polypeptide; 150kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DCTN1; DCTN1_HUMAN; DP 150; DP-150; DP150; Dynactin 1 (p150 Glued (Drosophila) homolog); Dynactin 1 (p150 glued homolog Drosophila); Dynactin 1; Dynactin subunit 1; Dynactin1; HMN7B; p135; p150 Glued (Drosophila) homolog ; p150 glued; p150 glued homolog; p150(GLUED) DROSOPHILA HOMOLOG OF; p150-glued; p150glued	Human	E. coli
	The DCTN1 protein is a central player in intracellular trafficking within the dynein complex, guiding dynein-driven retrograde movement along microtubules. It recruits dynein to microtubules, enhancing vesicle and organelle transport. DCTN1 Protein, Human (His-SUMO) is the recombinant human-derived DCTN1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of DCTN1 Protein, Human (His-SUMO) is 335 a.a., with molecular weight of ~55.2 kDa.

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	Dynein Light Chain Tctex Type 1 Antibody (YA3263) CW-1; TCTEL1; tctex-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Dynein Light Chain Tctex Type 1 Antibody (YA3263) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3263), targeting Dynein Light Chain Tctex Type 1, with a predicted molecular weight of 12 kDa (observed band size: 12 kDa). Dynein Light Chain Tctex Type 1 Antibody (YA3263) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

	Dynein Intermediate Chain 1 Antibody (YA3374) DNAI1; ICS; Immotile cilia syndrome 1; ICS1; CILD1; PCD	WB	Human, Mouse, Rat
	Dynein Intermediate Chain 1 Antibody (YA3374) is a non-conjugated IgG antibody, targeting Dynein Intermediate Chain 1, with a predicted molecular weight of 79 kDa (observed band size: 79 kDa). Dynein Intermediate Chain 1 Antibody (YA3374) can be used for WB experiment in human, mouse, rat background.

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