glycolate

By Targets:	Antibiotic (1) Bacterial (1) Biochemical Assay Reagents (2) Endogenous Metabolite (1) GnRH Receptor (1) Liposome (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Infection (1) Metabolic Disease (9)
Oligonucleotides:	Pegylated Lipids (1) siRNA drugs (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132588

Lumasiran ALN-G01	Small Interfering RNA (siRNA)	Metabolic Disease
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) .

HY-132613

Lumasiran sodium	Small Interfering RNA (siRNA)	Metabolic Disease
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-22166

Glycolic acid oxidase inhibitor 1	Others	Metabolic Disease
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.

HY-N2301

Pleuromutilin Drosophilin B; Mutilin 14-glycolate	Antibiotic Bacterial	Infection
Pleuromutilin (Drosophilin B) exhibits antibacterial activity through inhibition of protein synthesis .

HY-W250183B

Polyoxyethylene (20) stearyl ether Polyethylene glycol octadecyl ether (n～20)	Liposome	Others
Polyoxyethylene (20) stearyl ether (Polyethylene glycol octadecyl ether) is a polyethylene glycolated lipid surfactant that can be used in the formation and stabilization studies of nanoparticles .

HY-W176012

Glycolate oxidase-IN-1	Others	Metabolic Disease
Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC₅₀ of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1) .

HY-W088011B

*Sodium glycolate, 98%* Sodium hydroxyacetate, 98%	Biochemical Assay Reagents	Others
Sodium glycolate, 98% is a metal chelating agent.

HY-156648

Vamagloxistat	Others	Metabolic Disease
Vamagloxistat is glycolate oxidase inhibitor, used to inhibit hyperoxaluria and kidney stones .

HY-156648A

Vamagloxistat sodium	Biochemical Assay Reagents	Metabolic Disease
Vamagloxistat (sodium) is glycolate oxidase inhibitor, used to inhibit hyperoxaluria and kidney stones .

HY-138877

Phosphoglycolic acid	Endogenous Metabolite	Others
Phosphoglycolic acid intricately connects photo-respiration to central metabolism, influencing the tissue content of 2-phospho-glycolate.

HY-148610

LDH-IN-2	Others	Metabolic Disease
LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in hyperoxaluric hepatocytes. LDH-IN-2 can be used for research of primary hyperoxaluria type 1 (PH1) .

HY-P10378

GPR10 agonist 1	GnRH Receptor	Metabolic Disease
GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC₅₀ values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity .

Cat. No.	Product Name	Type

HY-W250183B

Polyoxyethylene (20) stearyl ether Polyethylene glycol octadecyl ether (n～20)	Surfactants
Polyoxyethylene (20) stearyl ether (Polyethylene glycol octadecyl ether) is a polyethylene glycolated lipid surfactant that can be used in the formation and stabilization studies of nanoparticles .

HY-W088011B

*Sodium glycolate, 98%* Sodium hydroxyacetate, 98%	Chelators
Sodium glycolate, 98% is a metal chelating agent.

HY-138877

Phosphoglycolic acid	Biochemical Assay Reagents
Phosphoglycolic acid intricately connects photo-respiration to central metabolism, influencing the tissue content of 2-phospho-glycolate.

Cat. No.	Product Name	Target	Research Area

HY-P4063

Pegylated synthetic human c-peptide	Peptides	Metabolic Disease
Pegylated synthetic human c-peptide retains bioactivity comparable to that of natural (i.e. non-polyethylene glycolated) C-peptides and has a prolonged circulating residence time in plasma for use in diabetic peripheral neuropathy studies .

HY-P10378

GPR10 agonist 1	GnRH Receptor	Metabolic Disease
GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC₅₀ values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2301

Pleuromutilin Drosophilin B; Mutilin 14-glycolate	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Antibiotic Bacterial
Pleuromutilin (Drosophilin B) exhibits antibacterial activity through inhibition of protein synthesis .

Species:	Human (1) Mouse (1)
Tag:	His (2) Trx (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70932

	HAO1 Protein, Human (Trx-His) Hydroxyacid Oxidase 1; HAOX1; glycolate Oxidase; GOX; HAO1; GOX1; HAOX1	Human	E. coli
	The HAO1 protein is a (S)-2-hydroxyacid oxidase with broad substrate specificity that facilitates glycolate oxidation. This activity produces glyoxylic acid, a key precursor for glycine synthesis. HAO1 Protein, Human (Trx-His) is the recombinant human-derived HAO1 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of HAO1 Protein, Human (Trx-His) is 370 a.a., with molecular weight of ~56.0 kDa.

HY-P71655

	Hydroxyacid oxidase 1 Protein, Mouse (His) Hao1; Gox1; Hao-1; Hydroxyacid oxidase 1; HAOX1; EC 1.1.3.15; glycolate oxidase; GOX	Mouse	E. coli
	Hydroxy acid oxidase 1 (HAO1) is a multifunctional (S)-2-hydroxyacid oxidase with a strong preference for glycolate oxidation. This enzymatic process produces glyoxylic acid, an important precursor for the synthesis of glycine by alanine glyoxylate aminotransferase, which prevents glyoxylic acid accumulation and kidney stone formation. Hydroxyacid oxidase 1 Protein, Mouse (His) is the recombinant mouse-derived Hydroxyacid oxidase 1 protein, expressed by E. coli , with N-His labeled tag.

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Cat. No.	Product Name		Classification

HY-132588

Lumasiran ALN-G01		siRNAs siRNA drugs
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) .

HY-132613

Lumasiran sodium		siRNAs siRNA drugs
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-W250183B

Polyoxyethylene (20) stearyl ether Polyethylene glycol octadecyl ether (n～20)		Pegylated Lipids
Polyoxyethylene (20) stearyl ether (Polyethylene glycol octadecyl ether) is a polyethylene glycolated lipid surfactant that can be used in the formation and stabilization studies of nanoparticles .

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glycolate

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