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Isoforms Recommended:	Adenosine A₃ receptor (A₃R)

Results for "

hA3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (20) Carbonic Anhydrase (1) Fluorescent Dye (1) Histamine Receptor (1) HIV (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (5)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	siRNAs (1)

Inhibitors & Agonists

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103174

MRS1334	Adenosine Receptor	Cardiovascular Disease
MRS1334 is a potent and selective human adenosine A₃ receptor antagonist with K_is of 2.69 nM, >100 nM, >100 nM for hA₃, rA₁, rA_2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment . MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103175

PSB36	Adenosine Receptor	Neurological Disease
PSB36 is a potent and selective antagonist of adenosine A₁ receptor, with K_is 0.12 nM, 187 nM, 552 nM, 2300 nM, and 6500 nM for rA₁, hA_2B, rA_2A, *hA₃* and rA₃ receptors respectively. PSB36 can be used for the research of hyperalgesia .

HY-139694

hA3AR agonist 1	Adenosine Receptor	Others
hA3AR agonist 1 is a potent human A₃ adenosine receptor (hA₃AR) agonist with a K_i value of 2.40 nM.

HY-158181

A3AR agonist 5	Adenosine Receptor	Inflammation/Immunology
A3AR agonist 5 (Compound 6b) is a A3 adenosine receptor (A3AR) activator, with EC₅₀ and K_i values of 0.14 nM and 6.36 nM for cAMP and hA3, respectively. A3AR agonist 5 can be used in pain and inflammatory research .

HY-158179

A3AR agonist 3	Adenosine Receptor	Neurological Disease
A3AR agonist 3 (Compound 15A) is a A3 adenosine receptor (A3AR) agonist, with K_i and EC₅₀ values of 2.27 and 0.20 nM for hA3 and cAMP, respectivelly. A3AR agonist 3 can be used for the research of neuroinflammation .

HY-118455

MRS1097	Adenosine Receptor	Neurological Disease
MRS1097 is a potent antagonist of *adenosine hA3* receptor, with the K_i** of 100 nM .

HY-134555

A3AR antagonist 4	Adenosine Receptor	Neurological Disease
A3AR antagonist 4 (Compd 1) is an *A3AR* antagonist, with K_i values of 30.8 nM (hA₃) and 203 nM (hA₁), repectively. A3AR antagonist 4 (Compd 1) can be used for the study of cerebral ischemia .

HY-147541

A2A/A3 AR antagonist-1	Adenosine Receptor	Inflammation/Immunology
A2A/A3 AR antagonist-1 (compound 23) is a dual A_2A/A₃ adenosine receptor (AR) fluorescent ligand, with K_is of 90 nM and 31.8 nM for hA_2A AR and hA₃ AR, respectively .

HY-110186

PQ-69	Adenosine Receptor	Metabolic Disease
PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a K_i value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (K_i=208 nM) and >1,000-fold selectivity over hA3 receptor (K_i >100 μM). PQ-69 can be used for the research of renal dysfunction .

HY-103177

PSB-10 hydrochloride	Adenosine Receptor	Inflammation/Immunology
PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A₃AR), with a K_i of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA₃ over rA₁, rA_2A, hA₁, hA_2A and hA_2B receptors (K_i=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice .

HY-RS09944

P4HA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P4HA3 Human Pre-designed siRNA Set A contains three designed siRNAs for P4HA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

P4HA3 Human Pre-designed siRNA Set A P4HA3 Human Pre-designed siRNA Set A

HY-122156

IMB-301	HIV	Infection
IMB-301 is a specific HIV-1 replication inhibitor that binds to **hA3G (human APOBEC3G)*, interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3*G. IMB-301 inhibits the replication of HIV-1 in H9 cells (IC₅₀=8.63 uM). Human APOBEC3G is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication .

HY-155772

LUF7690	Adenosine Receptor Fluorescent Dye	Inflammation/Immunology
LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .

HY-118678

MRS1186	Adenosine Receptor	Inflammation/Immunology
MRS1186 is a potent and selective human Adenosine A3 receptor *(hA₃AR)* antagonist, with a K_i of 7.66 nM.

HY-120090

MRS1177	Adenosine Receptor	Inflammation/Immunology
MRS1177 is a potent and selective human Adenosine A3 receptor *(hA₃AR)* antagonist, with a K_i of 0.3 nM.

HY-146979

hA2A/hCA XII modulator 1	Adenosine Receptor Carbonic Anhydrase	Cancer
hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA_2A adenosine receptor (hA_2AAR) antagonist with K_is of 6.4 nM, 4.819 μM, >30 μM for hA_2AAR, hA₁AR, hA₃AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with K_is of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research .

HY-12193

A-349821	Histamine Receptor	Others
A-349821 is a histamine H3 receptor antagonist characterized as a radioligand ([3H]-A-349821) for in vivo receptor occupancy assessment. In rats, [3H]-A-349821 penetrated the brain, showing higher levels in the cortex compared to the cerebellum, indicating selective H3 receptor binding. Its cortical occupancy was saturable, correlating with in vitro binding data. Inhibition studies with ABT-239 and other H3 antagonists showed dose-dependent reductions in receptor occupancy, matching blood levels associated with cognitive efficacy in preclinical models. [3H]-A-349821 thus serves as a valid tracer for H3 receptor occupancy, aiding in the development and clinical interpretation of H3 receptor antagonists .

HY-111809

N6-Ethyladenosine	Adenosine Receptor	Others
N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with K_is of 4.9 and 4.7 nM for hA₁AR and hA₃AR, respectively .

HY-161718

MRS8028	Adenosine Receptor	Inflammation/Immunology
MRS8028 is an agonist for A3 adenosine receptor (A3AR), which binds hA3AR with K_i of 2.44 nM. MRS8028 is potential for ameliorating ischemia and inflammatory diseases .

HY-103190

MRS1220	Adenosine Receptor	Neurological Disease Cancer
MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a K_i of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system . MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo .

HY-101854

N6-(2-Phenylethyl)adenosine N6-Phenethyladenosine; N6-Phenylethyladenosine	Adenosine Receptor	Inflammation/Immunology Cancer
N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent adenosine receptors (AR) agonist with K_i values of 11.8 nM, 30.1 nM, 0.63 nM for rat A₁AR, human A₁AR and hA₃AR, respectively .

HY-158180

A3AR agonist 4	Adenosine Receptor	Inflammation/Immunology
A3AR agonist 4 is an A3 adenosine receptor (A3AR) agonist (K_i: 1.24 nM for hA3AR). A3AR agonist 4 inhibits cAMP production with an EC₅₀ of 0.17 nM. A3AR agonist 4 can be used for research of inflammation and pain .

HY-162787

Adenosine receptor antagonist 5	Adenosine Receptor	Cancer
Adenosine receptor antagonist 5 (Compound 39) is a selective antagonist for human adenosine A3 receptor (hA3R) with K_i of 12 nM. Adenosine receptor antagonist 5 inhibits IB-MECA (HY-13591)-induced cAMP accumulation in NCI-H1792 cell, inhibits the proliferation of cancer cell LK-2 and NCI-H1792. Adenosine receptor antagonist 5 exhibits a fast metabolic rate in human liver microsomes .

Cat. No.	Product Name		Classification

HY-155772

LUF7690		Alkynes
LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .

Cat. No.	Product Name		Classification

HY-RS09944

P4HA3 Human Pre-designed siRNA Set A		siRNAs
P4HA3 Human Pre-designed siRNA Set A contains three designed siRNAs for P4HA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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