heart development

By Targets:	Adenosine Receptor (2) Apoptosis (1) Biochemical Assay Reagents (1) Cholinesterase (ChE) (1) Endogenous Metabolite (2) Herbicide (1) Monocarboxylate Transporter (1) Myosin (1) Potassium Channel (2)
By Research Areas:	Cardiovascular Disease (5) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101981

Uridine 5'-monophosphate 5'-Uridylic acid	Endogenous Metabolite Cholinesterase (ChE) Potassium Channel Apoptosis	Others
Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea .

HY-14873

Tonapofylline BG 9928	Adenosine Receptor	Cardiovascular Disease Metabolic Disease
Tonapofylline (BG 9928) is an orally active and selective adenosine A₁ receptor antagonist with a K_i of 7.4 nM for human adenosine A₁ receptor (hA₁), which displays 915-fold selectivity versus human adenosine A_2A receptor and 12-fold selectivity versus human adenosine A_2B receptor and is used in development for the treatment of heart failure .

HY-131948

3-Chlorodiphenylamine	Potassium Channel	Cardiovascular Disease
3-Chlorodiphenylamine is a high affinity Ca ²⁺ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (K_d=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca ²⁺-sensitizing compounds due to its small size, and can be used for systolic heart failure research .

HY-101981R

Uridine 5'-monophosphate (Standard) 5'-Uridylic acid (Standard)	Endogenous Metabolite	Others
Uridine 5'-monophosphate (Standard) is the analytical standard of Uridine 5'-monophosphate. This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

HY-10965

Rolofylline KW-3902	Adenosine Receptor	Neurological Disease
Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP₄₅₀) . Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases .

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%	Biochemical Assay Reagents	Cardiovascular Disease Others
omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-121287

Ioxynil	Herbicide	Cardiovascular Disease
Ioxynil is an herbicide that act as endocrine disruptor. Ioxynil can disrupt vascular and heart development in zebrafish .

HY-163120

Myosin-IN-1	Myosin	Cardiovascular Disease
Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research .

HY-114602

AR-C117977	Monocarboxylate Transporter	Inflammation/Immunology
AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse .

Cat. No.	Product Name

HY-L155

Mitochondrial Toxicity Compound Library	492 compounds
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity. MCE contains 492 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

Mitochondrial Toxicity Compound Library

492 compounds

Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.

MCE contains 492 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

HY-L029

Autophagy Compound Library	1,482 compounds
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 1,482 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Autophagy Compound Library

1,482 compounds

Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

MCE provides a unique collection of 1,482 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

HY-L123

Human Metabolite Library	6,258 compounds
Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development. MCE offers a unique collection of 6,258 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Human Metabolite Library

6,258 compounds

Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development.

MCE offers a unique collection of 6,258 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Cat. No.	Product Name	Type

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%	Drug Delivery
omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

omega-3 Arachidonic acid ethyl ester, in ethanol, 98%

ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%

Drug Delivery

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101981

Uridine 5'-monophosphate 5'-Uridylic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite Cholinesterase (ChE) Potassium Channel Apoptosis
Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea .

HY-101981R

Uridine 5'-monophosphate (Standard) 5'-Uridylic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Uridine 5'-monophosphate (Standard) is the analytical standard of Uridine 5'-monophosphate. This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

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