2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  3. Endogenous Metabolite Cholinesterase (ChE) Potassium Channel Apoptosis
  4. Uridine 5'-monophosphate

Uridine 5'-monophosphate  (Synonyms: 5'-​Uridylic acid)

Cat. No.: HY-101981 Purity: 98.20%
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Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

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Uridine 5'-monophosphate Chemical Structure

Uridine 5'-monophosphate Chemical Structure

CAS No. : 58-97-9

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Uridine 5'-monophosphate Related Antibodies

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Description

Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Microbial Metabolite

 

In Vitro

Uridine 5'-monophosphate (10 mM, 6 h) promotes late apoptosis in pig intestinal epithelial cells IPEC-J2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uridine 5'-monophosphate Related Antibodies

Apoptosis Analysis[1]

Cell Line: IPEC-J2
Concentration: 10 mM
Incubation Time: 6 h
Result: Increased the late apoptosis rate.
In Vivo

Uridine 5'-monophosphate (476 mg, oral, daily, 10 days) promotes apoptosis and renewal of intestinal villus tip epithelial cells in pigs, which benefits gut development and reduces the rate of diarrhea[1].
Uridine 5'-monophosphate (0.02-1 mmol/kg, i.g., single dose) can enhance the synthesis of CDP-choline in the brains of gerbils[2].
Uridine 5'-monophosphate (30 mg/kg, i.v., single dose) has protective properties for the heart in rats, preventing ischemic injury and some arrhythmias[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Piglets[1]
Dosage: 476 mg, daily, 10 days
Administration: Oral
Result: Improved daily weight gain in piglets, reduced diarrhea rates, lowered the expression of jejunal mucosal CAD and RRM2, and increased the apoptosis rate of intestinal epithelial cells.
Animal Model: Male gerbils (60-80g)[2]
Dosage: 0.02, 0.05, 0.1, 1 mmol/kg, single dose
Administration: i.g.
Result: Increased choline levels after 15 minutes, and after thirty minutes, plasma uridine and brain tissue uridine increased, with plasma and brain cytidine also rising significantly.
Animal Model: Male wistar rats (250–300 g)[4]
Dosage: 30 mg/kg, single dose
Administration: Intravenous injection (i.v.)
Result: Reduced the index of myocardial ischemia changes and T-wave amplitude, decreased the frequency of ventricular premature beats, and shortened the duration of ventricular tachycardia and fibrillation.
Molecular Weight

324.18

Formula

C9H13N2O9P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O)(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 150 mg/mL (462.71 mM; Need ultrasonic)

DMSO : 125 mg/mL (385.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0847 mL 15.4235 mL 30.8471 mL
5 mM 0.6169 mL 3.0847 mL 6.1694 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 3.75 mg/mL (11.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 3.75 mg/mL (11.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (308.47 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

SDS (393 KB)

COA (254 KB) HNMR (113 KB) RP-HPLC (231 KB) MS (78 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.0847 mL 15.4235 mL 30.8471 mL 77.1177 mL
5 mM 0.6169 mL 3.0847 mL 6.1694 mL 15.4235 mL
10 mM 0.3085 mL 1.5424 mL 3.0847 mL 7.7118 mL
15 mM 0.2056 mL 1.0282 mL 2.0565 mL 5.1412 mL
20 mM 0.1542 mL 0.7712 mL 1.5424 mL 3.8559 mL
25 mM 0.1234 mL 0.6169 mL 1.2339 mL 3.0847 mL
30 mM 0.1028 mL 0.5141 mL 1.0282 mL 2.5706 mL
40 mM 0.0771 mL 0.3856 mL 0.7712 mL 1.9279 mL
50 mM 0.0617 mL 0.3085 mL 0.6169 mL 1.5424 mL
60 mM 0.0514 mL 0.2571 mL 0.5141 mL 1.2853 mL
80 mM 0.0386 mL 0.1928 mL 0.3856 mL 0.9640 mL
100 mM 0.0308 mL 0.1542 mL 0.3085 mL 0.7712 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Uridine 5'-monophosphate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine 5'-monophosphate58-97-95'-​Uridylic acidEndogenous MetaboliteCholinesterase (ChE)Potassium ChannelApoptosisKcsAIntestinal developmentHeart protectionCell apoptosisInhibitorinhibitorinhibit

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