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Results for "

hypercholesterolemic

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

4

Peptides

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101812
    Terbufibrol

    		Others Metabolic Disease
    Terbufibrol has been shown highly active in reducing serum total cholesterol (TC) levels in the normal and hypercholesterolemic male rat.
    Terbufibrol
  • HY-118824A
    N-Feruloylserotonin

    (E/Z)-Moschamine

    		 Others Cardiovascular Disease
    N-Feruloylserotonin, an antioxidative component and bioactive serotonin derivative, from the Seed of Carthamus tinctorius L., ameliorates atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits .
    N-Feruloylserotonin
  • HY-34781
    4'-Trifluoromethyl-2-biphenyl carboxylic acid

    		Others Cardiovascular Disease Metabolic Disease
    4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent .
    4'-Trifluoromethyl-2-biphenyl carboxylic acid
  • HY-106281A
    Bemfivastatin hemicalcium

    PPD 10558 hemicalcium

    		 HMG-CoA Reductase (HMGCR) Cardiovascular Disease Metabolic Disease
    Bemfivastatin (PPD 10558) hemicalcium is an orally active lipid-lowering agent and HMG-CoA reductase inhibitor. Bemfivastatin hemicalcium enhances the activity of liver extracts. Bemfivastatin hemicalcium has no-observed adverse effect levels (NOAEL) with dosages of ≥320 mg/kg/d (rat developmental toxicity), ≥12.5 mg/kg/d (rabbit maternal toxicity), ≥25 mg/kg/d (rabbit developmental toxicity), respectively. Bemfivastatin hemicalcium can be used in the study of statin-related hypercholesterolemic myalgia in statin-intolerant patients.
    Bemfivastatin hemicalcium
  • HY-P10586A
    Macrophage-activating lipopeptide 2 TFA

    MALP-2 TFA

    		 Toll-like Receptor (TLR) NO Synthase Cardiovascular Disease Metabolic Disease
    Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .
    Macrophage-activating lipopeptide 2 TFA
  • HY-106281
    Bemfivastatin

    PPD 10558

    		 HMG-CoA Reductase (HMGCR) Cardiovascular Disease Metabolic Disease
    Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor, also known as Statin. Bemfivastatin enhances the activity of liver extraction. Bemfivastatin exhibits little developmental toxicity effects in pregnant rats and rabbits via daily oral doses during organogenesis period. The no observed adverse effect level (NOAEL) are ≥320 mg/kg/day for rats developmental toxicity, 12.5 mg/kg/day for rabbits maternal toxicity, and 25 mg/kg/day for rabbits developmental toxicity, respectively. Bemfivastatin can be used for research on Statin-related hypercholesterolemic myalgia with inability to tolerate statins .
    Bemfivastatin
  • HY-P10872
    P315V3

    		SARS-CoV Infection
    P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC50s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC50 of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .
    P315V3
  • HY-122933
    Kurarinol

    		Tyrosinase Apoptosis Cardiovascular Disease Cancer
    Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase .
    Kurarinol
  • HY-P10586
    Macrophage-activating lipopeptide 2

    MALP-2

    		 Toll-like Receptor (TLR) NO Synthase Cardiovascular Disease
    Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .
    Macrophage-activating lipopeptide 2

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