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inactivators

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By Targets:	Bacterial (2) Btk (2) Cytochrome P450 (6) Drug Metabolite (2) EGFR (1) Fungal (2) GABA Receptor (2) Histone Methyltransferase (1) IGF-1R (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (1) SARS-CoV (1) Thrombin (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Infection (5) Inflammation/Immunology (3) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid	Cytochrome P450 Interleukin Related EGFR IGF-1R	Infection Others Cancer
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-N2229

Rhapontigenin 1 Publications Verification	Cytochrome P450 Fungal Bacterial	Infection Inflammation/Immunology Cancer
Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1?inactivator (IC₅₀ ?= 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively .

HY-N2233

Rhapontigenin 3'-O-glucoside 1 Publications Verification	Cytochrome P450	Cancer
Rhapontigenin 3'-O-glucoside is a derivative of Rhapontigenin. Rhapontigenin is a potent inactivator of human P450 1A1 and is a good candidate for a cancer chemopreventive agent .

HY-W012738

DL-Pyroglutamic acid	Influenza Virus GABA Receptor	Infection
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action .

HY-107931

Propiolactone β-propiolactone; 2-Oxetanone; Betaprone	SARS-CoV	Infection
Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL) .

HY-N8278

Dermatan sulphate sodium	Thrombin	Cardiovascular Disease Inflammation/Immunology
Dermatan sulphate sodium is a glycosaminoglycan and thrombin inactivator with antithrombotic activity. Dermatan sulphate sodium selectively catalyzes the inactivation of thrombin by heparin cofactor II and does not interact with antithrombin III. Dermatan sulphate sodium is highly bioavailable and also reduces Bleomycin (HY-108345)-induced pulmonary fibrosis damage .

HY-135334

ACP-5862 1 Publications Verification	Drug Metabolite Btk Cytochrome P450	Cancer
ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC₅₀ of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC₅₀ of 3 nM and EC₅₀ of 8 nM .

HY-116910

CPP-115	GABA Receptor	Neurological Disease
CPP-115 is a GABA transaminase inactivator with higher affinity and lower retinal toxicity than Vigabatrin (HY-15399). CPP-115 increases brain GABA levels by inhibiting GABA transaminase catabolism. CPP-115 can be used in the study of drug addiction and infantile spasms .

HY-114056

AS115	Others	Cancer
AS115 is a potent and selective KIAA1363 inactivator with IC₅₀ value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues .

HY-143438

2-PAT	Monoamine Oxidase	Neurological Disease
2-PAT, an analogue of Rasagiline and Selegiline, a reversible MAO-A inhibitor with an IC₅₀ of 0.721 µM. 2-PAT is an inactivator of MAO-B with an IC₅₀ of 14.6 µM. 2-PAT has the potential for Parkinson’s disease and depression research .

HY-P1182

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

HY-N2229R

Rhapontigenin (Standard)	Cytochrome P450 Fungal Bacterial	Infection Inflammation/Immunology Cancer
Rhapontigenin (Standard) is the analytical standard of Rhapontigenin. This product is intended for research and analytical applications. Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC₅₀ = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively .

HY-135334S

ACP-5862-d4	Isotope-Labeled Compounds Drug Metabolite Btk Cytochrome P450	Cancer
ACP-5862-d₄ is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[1][2].

Cat. No.	Product Name	Target	Research Area

HY-P1182

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Piperaceae Plants Disease Research Fields Piper nigrum Linn.	Cytochrome P450 Interleukin Related EGFR IGF-1R
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-N2229

Rhapontigenin 1 Publications Verification	Infection Structural Classification Stilbenes Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Trigonella foenum-graecum Linn. Inflammation/Immunology Disease Research Fields	Cytochrome P450 Fungal Bacterial
Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1?inactivator (IC₅₀ ?= 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively .

HY-N2233

Rhapontigenin 3'-O-glucoside 1 Publications Verification	Structural Classification other families Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Cytochrome P450
Rhapontigenin 3'-O-glucoside is a derivative of Rhapontigenin. Rhapontigenin is a potent inactivator of human P450 1A1 and is a good candidate for a cancer chemopreventive agent .

HY-N8278

Dermatan sulphate sodium	Structural Classification Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Thrombin
Dermatan sulphate sodium is a glycosaminoglycan and thrombin inactivator with antithrombotic activity. Dermatan sulphate sodium selectively catalyzes the inactivation of thrombin by heparin cofactor II and does not interact with antithrombin III. Dermatan sulphate sodium is highly bioavailable and also reduces Bleomycin (HY-108345)-induced pulmonary fibrosis damage .

HY-N2229R

Rhapontigenin (Standard)	Structural Classification Stilbenes Leguminosae Source classification Phenols Polyphenols Plants Trigonella foenum-graecum Linn.	Cytochrome P450 Fungal Bacterial
Rhapontigenin (Standard) is the analytical standard of Rhapontigenin. This product is intended for research and analytical applications. Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC₅₀ = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively .

Cat. No.	Product Name	Chemical Structure

HY-135334S

ACP-5862-d4
ACP-5862-d₄ is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[1][2].

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inactivators

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products