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metallo-β-lactamase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Beta-lactamase (29) Angiotensin-converting Enzyme (ACE) (4) Apoptosis (7) Autophagy (3) Bacterial (21) Bcl-2 Family (1) Endogenous Metabolite (2) HDAC (9) Isotope-Labeled Compounds (1) Virus Protease (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (5) Infection (25) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Beta-lactamase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150758

NDM-1 inhibitor-3	Beta-lactamase Bacterial	Infection
NDM-1 inhibitor-3 (Compound 89) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor with a K_i of 4 μM .

HY-168500

Metallo-β-lactamase-IN-16	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing *metallo-β-lactamase* inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC₅₀ values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively .

HY-163338

Metallo-β-lactamase-IN-13	Beta-lactamase	Infection
Metallo-β-lactamase-IN-13 (Compound 13i) is a pan *Metallo-β-Lactamase* inhibitor. Metallo-β-lactamase-IN-13 provides broader coverage of metallo-β-lactamases expressing Gram-negative (GN) bacteria. Metallo-β-lactamase-IN-13 has antibacterial activity against P. aeruginosa .

HY-163339

Metallo-β-lactamase-IN-14	Beta-lactamase	Infection
Metallo-β-lactamase-IN-14 (Compound 17e) is a *Metallo-β-Lactamase* inhibitor. Metallo-β-lactamase-IN-14 shows inhibition activity against VIM-1 and VIM-2. Metallo-β-lactamase-IN-14 has antibacterial activity against Gram-negative (GN) bacteria and P. aeruginosa .

HY-155202

YJ196	Others	Others
YJ196 (Compound 59) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor .

HY-143415

Metallo-β-lactamase-IN-7	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC₅₀s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains .

HY-117951

ANT431	Beta-lactamase	Infection
ANT431 is a metallo-β-lactamase inhibitor that also restores the effectiveness of Meropenem (HY-13678) in a mouse thigh Escherichia coli infection model .

HY-162174

MBL-IN-2	Beta-lactamase Bacterial	Infection
MBL-IN-2 ((2R, 2R')-5αC) is an inhibitor of Metallo-β-lactamase (MBL) that can inhibit *New Delhi Metallo-β-lactamase-1 (NDM-1)* with an IC₅₀ of 0.3 μM. MBL-IN-2 ((2R, 2R')-5αC) can be used for the study of resistance to β-lactam antibiotics .

HY-146637

VIM-2-IN-1	Beta-lactamase Bacterial	Infection
VIM-2-IN-1 (compound 1dj) is a *β-lactamase* inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC₅₀ values of 23 µM, 48 µM and 231 µM for *Verona integron-encoded metallo-β-lactamase* (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1)**, respectively .

HY-143414

Metallo-β-lactamase-IN-6	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-6 is a potent VIM-Type *metallo-β-lactamase* inhibitor with IC₅₀s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL .

HY-155283

Zndm19	Beta-lactamase Bacterial	Infection
Zndm19 is a *New Delhi Metallo-β-lactamase-1 (NDM-1)* inhibitor. Zndm19 can be used for the research of drug-resistant bacterial infections .

HY-100871

WT-161 5+ Cited Publications	Beta-lactamase HDAC Apoptosis	Cancer
WT-161 is a potent and selective HDAC6 inhibitor with an IC₅₀ of 0.40 nM . WT-161 also inhibits metallo-β-lactamase domain-containing protein?2 (MBLAC2) .

HY-144659

Metallo-β-lactamase-IN-5	Beta-lactamase Apoptosis Bacterial	Infection
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC₅₀ of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .

HY-13428

Tubacin 10+ Cited Publications	Beta-lactamase HDAC Virus Protease	Cancer
Tubacin is a potent and selective inhibitor of HDAC6, with an IC₅₀ value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).

HY-19328

ACY-775 2 Publications Verification	HDAC	Cardiovascular Disease Neurological Disease
ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC₅₀ of 7.5 nM . ACY775 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) .

HY-10990

Abexinostat 5+ Cited Publications CRA 024781; PCI-24781	HDAC	Cancer
Abexinostat (CRA 024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with K_i of 7 nM. Abexinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC₅₀ below 10 nM .

HY-149929

EBL-3183	Beta-lactamase Bacterial	Infection
EBL-3183, an indole-2-carboxylate, is a potent metallo-β-lactamase (MBL) inhibitor. EBL-3183 is reversibly binding, non-covalent, competitive NDM-1 inhibitor with a pIC₅₀ of 7.7 .

HY-155504

Metallo-β-lactamase-IN-11	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-11 (compound 5f) is a *Metallo-β-lactamases* (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC₅₀=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance .

HY-144261

Metallo-β-lactamase-IN-3	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC₅₀ of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7 .

HY-13322

Pracinostat 5+ Cited Publications SB939	Beta-lactamase HDAC Apoptosis	Cancer
Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC₅₀s of 40-140 nM, used for cancer research. Pracinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC₅₀ below 10 nM .

HY-105246

Pracinostat dihydrochloride	Beta-lactamase HDAC Apoptosis	Cancer
Pracinostat dihydrochloride is a potent histone deacetylase (HDAC) inhibitor, with IC₅₀s of 40-140 nM, used for cancer research. Pracinostat dihydrochloride also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC₅₀ below 10 nM .

HY-12826

IMB-XH1	Beta-lactamase Bcl-2 Family Bacterial	Cancer
IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1) . IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC₅₀s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively .

HY-144100

β-Lactamase-IN-7	Beta-lactamase Bacterial	Infection
β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with K_is of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae .

HY-152105

Metallo-β-lactamase-IN-9	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC₅₀s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively .

HY-146165

Metallo-β-lactamase-IN-8	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC₅₀s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity .

HY-13271

Tubastatin A Hydrochloride Maximum Cited Publications 24 Publications Verification Tubastatin A HCl; TSA HCl	Beta-lactamase HDAC Autophagy Apoptosis	Cancer
Tubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6* inhibitor* with IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A Hydrochloride also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

HY-13271A

Tubastatin A Maximum Cited Publications 24 Publications Verification	Beta-lactamase HDAC Autophagy Apoptosis	Cancer
Tubastatin A is a potent and selective HDAC6* inhibitor* with an IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

HY-144259

Metallo-β-lactamase-IN-2	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC₅₀ values of 0.1 μM (VIM-1), 1.3 μM (NDM-1), and 5.0 μM (IMP-7), respectively .

HY-144262

Metallo-β-lactamase-IN-4	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC₅₀ values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively .

HY-13271B

Tubastatin A TFA TSA TFA	HDAC Autophagy Apoptosis	Cancer
Tubastatin A (TSA) TFA is a potent and selective?HDAC6?inhibitor with?IC₅₀?of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A TFA also inhibits HDAC10 and metallo-β-lactamase domain-containing protein?2 (MBLAC2).

HY-B0368

Captopril 15+ Cited Publications SQ 14225	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-B0368A

Captopril hydrochloride SQ 14225 hydrochloride	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Captopril (SQ 14225) hydrochloride, antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril hydrochloride is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-B0368S

Captopril-d3 SQ 14225-d₃	Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM[1][2][3].

HY-162493

MBL-IN-3	Bacterial	Infection
MBL-IN-3 (compound 72922413) is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor(IC₅₀=54±4 μM). MBL-IN-3 is identified and shown to lower minimum inhibitory concentrations (MICs) of Meropenem (HY-13678) for a panel of E. coli and K. pneumoniae clinical isolates expressing NDM-1. MBL-IN-3 can be used for antibiotic sensitizer research .

HY-118013

NDM-1 inhibitor-2	Others	Infection
NDM-1 inhibitor-2 is an inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) and has the ability to inhibit NDM-1 activity. NDM-1 inhibitor-2 exhibits a good inhibitory effect on drug-resistant bacterial strains that overexpress NDM-1. When NDM-1 inhibitor-2 is used in combination with the carbapenem antibiotic meropenem, a favorable synergistic effect can be produced .

HY-148493

MK-3402	Bacterial	Infection
MK-3402 is a *metallo-beta-lactamase* inhibitor (Example 303 in reference patent). MK-3402can be used in the research of bacteria .

HY-136306

Metallo β-lactamase ligand 1	Beta-lactamase Bacterial	Infection
Metallo-beta-lactamase ligand 1 is a class B *β-lactamase* inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A .

HY-161094

Metallo-β-lactamase-IN-12	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and *serine β-lactamases* (SβLs (OXA-48, KPC-2)), with IC₅₀** values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity .

HY-B0368R

Captopril (Standard)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Captopril (Standard) is the analytical standard of Captopril. This product is intended for research and analytical applications. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM .

HY-161310

Metallo-β-lactamase-IN-15	Beta-lactamase	Infection
Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC₅₀ values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively .

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Endogenous Metabolite	Metabolic Disease
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less *New Delhi metallo-beta-lactamase-1 (NDM-1)* inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-121765R

Dacisteine (Standard) N,S-Diacetyl-L-cysteine (Standard)	Endogenous Metabolite	Metabolic Disease
Dacisteine (Standard) is the analytical standard of Dacisteine. This product is intended for research and analytical applications. Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less *New Delhi metallo-beta-lactamase-1 (NDM-1)* inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less *New Delhi metallo-beta-lactamase-1 (NDM-1)* inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-121765R

Dacisteine (Standard) N,S-Diacetyl-L-cysteine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Dacisteine (Standard) is the analytical standard of Dacisteine. This product is intended for research and analytical applications. Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less *New Delhi metallo-beta-lactamase-1 (NDM-1)* inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

Cat. No.	Product Name	Chemical Structure

HY-B0368S

Captopril-d3
Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM[1][2][3].

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