1. Anti-infection Epigenetics Cell Cycle/DNA Damage Apoptosis
  2. Beta-lactamase HDAC Apoptosis
  3. Pracinostat dihydrochloride

Pracinostat dihydrochloride is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat dihydrochloride also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM.

For research use only. We do not sell to patients.

Pracinostat dihydrochloride Chemical Structure

Pracinostat dihydrochloride Chemical Structure

CAS No. : 929016-98-8

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Description

Pracinostat dihydrochloride is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat dihydrochloride also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM[1][4].

IC50 & Target

IC50: 40 nM (HDAC10), 43 nM (HDAC3), 47 nM (HDAC5), 49 nM (HDAC1), 56 nM (HDAC4), 70 nM (HDAC9), 93 nM (HDAC11), 96 nM (HDAC2), 137 nM (HDAC7), 140 nM (HDAC8), 1008 nM (HDAC6)[1]

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
0.48 μM
Compound: 3, SB939
Antiproliferative activity against human A2780 cells after 96 hrs by celltiter 96 assay
Antiproliferative activity against human A2780 cells after 96 hrs by celltiter 96 assay
[PMID: 21634430]
COLO 205 IC50
0.56 μM
Compound: 3, SB939
Antiproliferative activity against human COLO205 cells after 96 hrs by celltiter 96 assay
Antiproliferative activity against human COLO205 cells after 96 hrs by celltiter 96 assay
[PMID: 21634430]
HCT-116 IC50
0.48 μM
Compound: 3, SB939
Antiproliferative activity against human HCT116 cells after 96 hrs by celltiter 96 assay
Antiproliferative activity against human HCT116 cells after 96 hrs by celltiter 96 assay
[PMID: 21634430]
PC-3 IC50
0.34 μM
Compound: 3, SB939
Antiproliferative activity against human PC3 cells after 96 hrs by celltiter 96 assay
Antiproliferative activity against human PC3 cells after 96 hrs by celltiter 96 assay
[PMID: 21634430]
Molecular Weight

431.40

Formula

C20H32Cl2N4O2

CAS No.
SMILES

CCN(CCN1C2=CC=C(C=C2N=C1CCCC)/C=C/C(NO)=O)CC.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pracinostat dihydrochloride
Cat. No.:
HY-105246
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