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Results for "

myosin II

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Myosin (16) Autophagy (1) CaMK (2) Casein Kinase (1) Drug Derivative (1) Na+/K+ ATPase (1) PKA (1) PKC (1) Potassium Channel (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (6) Metabolic Disease (3) Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Targets Recommended: Myosin Photosystem II CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152190

JB002	Myosin	Cardiovascular Disease
JB002 is a myosin II inhibitor, with an IC₅₀ of ≤10 μM. JB002 can be used for the research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .

HY-16690

BTS 2 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of *skeletal muscle myosin* II subfragment 1 (S1) ATPase activity, with an IC₅₀*s of ~5 μM for actin- and Ca ²⁺-stimulated myosin* S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

HY-120870

para-Nitroblebbistatin 1 Publications Verification	Myosin	Metabolic Disease
para-Nitroblebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies .

HY-107657

(+)-Blebbistatin 1 Publications Verification	Myosin	Others
(+)-Blebbistatin is the inactive enantiomer of (–)-Blebbistatin. (–)-Blebbistatin is a selective inhibitor of myosin II ATPase .

HY-13441

(-)-Blebbistatin 10+ Cited Publications	Myosin	Cardiovascular Disease Cancer
(-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II .

HY-152205

JB061	Myosin	Others
JB061 is a nonmuscle myosin inhibitor with IC₅₀s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (*Smooth muscle myosin* II), respectively. JB061 poorly decreases ATPase activity (IC₅₀>200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC₅₀** value of 39 μM .

HY-129452

(S)-3'-Hydroxy blebbistatin	Myosin	Others
(S)-3'-Hydroxy blebbistatin is a myosin II inhibitor and is more water-soluble than Blebbistatin .

HY-133885

S-(-)-7-Desmethyl-8-nitro blebbistatin	Drug Derivative	Others
S-(-)-7-Desmethyl-8-nitro blebbistatin (compound 12) is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor .

HY-152206

JB062	Myosin	Neurological Disease
JB062 is a nonmuscle myosin inhibitor with IC₅₀ values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .

HY-169183

Myokinasib-II	Myosin	Cancer
Myokinasib-II is a *myosin* light chain kinase (MLCK) inhibitor, which is a potential target for inflammatory diseases, cancer and other diseases. .

HY-Y0413

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Cardiovascular Disease Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle *myosin-II*. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

HY-133885A

R-(-)-7-Desmethyl-8-nitro blebbistatin	Myosin	Cardiovascular Disease
R-(-)-7-Desmethyl-8-nitro blebbistatin is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor.

HY-13441G

(-)-Blebbistatin (GMP)	Myosin	Cardiovascular Disease Cancer
(-)-Blebbistatin (GMP) is (-)-Blebbistatin (HY-13441) produced by using GMP guidelines. (-)-Blebbistatin (GMP) is a selective inhibitor of the ATPase activity of non-muscle myosin II .

HY-111474

Para-aminoblebbistatin	Myosin	Cardiovascular Disease Neurological Disease
Para-aminoblebbistatin is a highly water soluble, non-fluorescent and photostable C15 amino-substituted derivative of blebbistatin; inhibits various (myosin II) isoforms both in vitro and in vivo.

HY-P1029

MLCK inhibitor peptide 18 4 Publications Verification	Myosin CaMK Autophagy	Others
MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC₅₀ of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.

HY-123634

(S)-3'-Aminoblebbistatin	Myosin	Others
(S)-3'-Aminoblebbistatin is the derivative of Blebbistatin (HY-13813). (S)-3'-Aminoblebbistatin exhibits inhibitory activity against myosin II with an IC₅₀ of 14.1 µM .

HY-13813

Blebbistatin Maximum Cited Publications 22 Publications Verification	Myosin	Others
Blebbistatin is a selective *non-muscle myosin* II (NMII)** inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration .

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 μM), casein kinase II (K_i=5.1 μM) and myosin light chain kinase (MLCK) (K_i=7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 μM and 80 μM, respectively .

HY-102052

DCEBIO	Potassium Channel	Metabolic Disease
DCEBIO is a small/medium conductance calcium-activated potassium (SK_Ca/IK_Ca) channel opener and primary neuron signal blocker. It hyperpolarizes the membrane potential of C2C12 myoblasts by activating IK_Ca channels, thereby promoting myogenic differentiation. The specific biological activity of DCEBIO is manifested in increased myotube formation, enhanced myosin heavy chain II protein levels and myogenin mRNA levels. DCEBIO can be applied in the field of muscle research, especially in muscle-related degenerative diseases such as sarcopenia .

Cat. No.	Product Name	Type

HY-133885

S-(-)-7-Desmethyl-8-nitro blebbistatin	Dyes
S-(-)-7-Desmethyl-8-nitro blebbistatin (compound 12) is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor .

HY-13441G

(-)-Blebbistatin (GMP)	Fluorescent Dye
(-)-Blebbistatin (GMP) is (-)-Blebbistatin (HY-13441) produced by using GMP guidelines. (-)-Blebbistatin (GMP) is a selective inhibitor of the ATPase activity of non-muscle myosin II .

(-)-Blebbistatin (GMP)	Biochemical Assay Reagents
(-)-Blebbistatin (GMP) is (-)-Blebbistatin (HY-13441) produced by using GMP guidelines. (-)-Blebbistatin (GMP) is a selective inhibitor of the ATPase activity of non-muscle myosin II .

Cat. No.	Product Name	Target	Research Area

HY-P1029

MLCK inhibitor peptide 18 4 Publications Verification	Myosin CaMK Autophagy	Others
MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC₅₀ of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.

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