nerve stimulation

By Targets:	5-HT Receptor (2) Adrenergic Receptor (1) Angiotensin Receptor (1) Biochemical Assay Reagents (1) Bombesin Receptor (1) Cholinesterase (ChE) (1) Endogenous Metabolite (2) mAChR (1) mGluR (1) Mitochondrial Metabolism (1) nAChR (1) Neurokinin Receptor (1) Potassium Channel (1) Sodium Channel (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (14)

Targets Recommended: Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116795

5-Methoxy-α-ethyltryptamine	5-HT Receptor	Neurological Disease
5-Methoxy-α-ethyltryptamine is a tryptamine psychoactive substance, which has nerve stimulated effect .

HY-N11004

Erinacine C	Others	Neurological Disease
Erinacine C is a potent stimulator. Erinacine C can be used for nerve-growth factor synthesis .

HY-W129456

Isaxonine	Biochemical Assay Reagents	Neurological Disease
Isaxonine acts as a modifier of the surface pH of the bilayer . Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery . Isaxonine is a neurotrophic agent .

HY-N8028

Quercetin 3-O-sambubioside 1 Publications Verification	Others	Cancer
Quercetin-3-O-sambubioside is a monomeric compound found in Eucommia ulmoides male flowers. Quercetin-3-O-sambubioside promotes the stimulation of the nerve center. Antioxidant and anticancer activities .

HY-110304

NPEC-caged-LY379268	mGluR	Neurological Disease
NPEC-caged-LY379268 is a type II mGluR agonist .

HY-W751874

Acetyl methylene blue	Mitochondrial Metabolism	Neurological Disease
Acetyl methylene blue can be used to synthesize mitochondrial development stimulators, which can be used for eye diseases related to insufficient mitochondrial function in nerve cells .

HY-N12566

Erinacin B	Others	Neurological Disease
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-B1382A

Pempidine hydrochloride 1,2,2,6,6-Pentamethylpiperidine hydrochloride	nAChR	Cardiovascular Disease Neurological Disease
Pempidine (1,2,2,6,6-Pentamethylpiperidine) hydrochloride is an orally active ganglionic blocking agent used in the treatment of hypertension. Pempidine hydrochloride blocks the effects of intravenously administered addictive drugs and peripheral vagal nerve stimulation on blood pressure, and reduces the output of acetylcholine .

HY-105747A

Guanoxyfen nitrate N-(3-Phenoxypropyl)guanidine nitrate; (3-Phenoxypropyl)guanidine nitrate	Endogenous Metabolite	Infection Neurological Disease
Guanoxyfen (N-(3-Phenoxypropyl)guanidine) nitrate is a compound that exhibits potent inhibitory activity against the serine protease enzyme TMPRSS2, which plays a crucial role in the infectivity of coronaviruses. Guanoxyfen nitrate is also an effective inhibitor of vasoconstrictor responses to sympathetic nerve stimulation.

HY-14149A

Cisapride monohydrate R 51619 monohydrate; (±)-Cisaprid monohydrate	5-HT Receptor	Neurological Disease Metabolic Disease
Cisapride monohydrate is an orally and potent 5-HT₄ receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut .

HY-U00079A

Vamicamide FK-176	mAChR	Neurological Disease
Vamicamide (FK-176) is an orally active competitive mAChR antagonist that inhibits contractions induced by cholinergic nerve stimulation by preventing mAChR agonists from binding to mAChR. Vamicamide exhibits a good anti-bladder spasm effect, with a pA2 value of 6.82 in bladder tissue. Vamicamide can be used in research within the field of neurological diseases .

HY-P3225

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate	Bombesin Receptor Neurokinin Receptor	Neurological Disease Inflammation/Immunology
(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate) is an antagonist for Substance P (HY-P0201) and Bombesin (HY-P0195) that has effects on ocular inflammatory responses to antidromic trigeminal nerve stimulation .

HY-W027553

Ipidacrine NIK-247 free base	Cholinesterase (ChE) Potassium Channel Sodium Channel	Neurological Disease Metabolic Disease
Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K ⁺ and Na ⁺-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

HY-N0667R

L-Asparagine (Standard)	Endogenous Metabolite	Neurological Disease Cancer
L-Asparagine (Standard) is the analytical standard of L-Asparagine. This product is intended for research and analytical applications. L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity . In Vitro:L-Asparagine (0.03 mM) can reverse the proliferation decline of six human cancer cells induced by ASNS siRNA knockdown . L-Asparagine (10 mM, 4 h) can stimulate ODC activity and proliferation in IPEC-J2 cells .

HY-16094

Bethanidine sulfate BW 467C60	Adrenergic Receptor	Neurological Disease
Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neurone blockers with sympathomimetic effects similar to bretylium and guanethidine in various animal models, particularly in cats. They inhibit the release of noradrenaline during nerve stimulation and enhance smooth muscle responses to adrenaline and noradrenaline. Bethanidine sulfate increases pressor responses to tyramine, though this effect diminishes with higher doses. Unlike guanethidine, Bethanidine sulfate does not deplete pressor amine content in the iris of cats post-administration. It also briefly inhibits autonomic cholinergic mechanisms and causes temporary neuromuscular paralysis in large doses, contrasting with its prolonged adrenergic neurone blocking effects .

HY-103247

EMD 66684	Angiotensin Receptor	Cardiovascular Disease
EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC₅₀ value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant ^- .

Cat. No.	Product Name

HY-L139

Pain-Related Compound Library	2,354 compounds
Pain is a kind of distressing feeling caused by the stimulation of tissue damage. According to the International Association for the Study of Pain (IASP), pain is defined as ”An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”. Pain is usually classified according to its location, duration, underlying causes, and intensity. For example, acute and chronic pain, muscle pain, and nerve pain. Pain is the main symptom of most diseases, which seriously affects the quality of life and body function of patients. In the medical treatment of pain, anti-inflammatory drugs and opioid analgesic agents have traditionally been used, but the side effects are serious. In recent years, targeted drugs targeting the ERK/MAPK pathway or other targets have gradually become a research hotspot. MCE supplies a unique collection of 2,354 compounds targeting key proteins in the pain system. MCE Pain-Related Compound Library is a useful tool for pain related research and anti-pain drug development.

Pain-Related Compound Library

2,354 compounds

Pain is a kind of distressing feeling caused by the stimulation of tissue damage. According to the International Association for the Study of Pain (IASP), pain is defined as ”An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”.

Pain is usually classified according to its location, duration, underlying causes, and intensity. For example, acute and chronic pain, muscle pain, and nerve pain. Pain is the main symptom of most diseases, which seriously affects the quality of life and body function of patients. In the medical treatment of pain, anti-inflammatory drugs and opioid analgesic agents have traditionally been used, but the side effects are serious. In recent years, targeted drugs targeting the ERK/MAPK pathway or other targets have gradually become a research hotspot.

MCE supplies a unique collection of 2,354 compounds targeting key proteins in the pain system. MCE Pain-Related Compound Library is a useful tool for pain related research and anti-pain drug development.

Cat. No.	Product Name	Type

HY-W751874

Acetyl methylene blue	Dyes
Acetyl methylene blue can be used to synthesize mitochondrial development stimulators, which can be used for eye diseases related to insufficient mitochondrial function in nerve cells .

Cat. No.	Product Name	Target	Research Area

HY-P3225

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate	Bombesin Receptor Neurokinin Receptor	Neurological Disease Inflammation/Immunology
(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate) is an antagonist for Substance P (HY-P0201) and Bombesin (HY-P0195) that has effects on ocular inflammatory responses to antidromic trigeminal nerve stimulation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11004

Erinacine C	Structural Classification Human Gut Microbiota Metabolites Microorganisms Terpenoids Source classification Diterpenoids Endogenous metabolite	Others
Erinacine C is a potent stimulator. Erinacine C can be used for nerve-growth factor synthesis .

HY-N8028

Quercetin 3-O-sambubioside 1 Publications Verification	Flavonols Eucommia ulmoides Oliver Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Eucommiaceae Plants Disease Research Fields Cancer	Others
Quercetin-3-O-sambubioside is a monomeric compound found in Eucommia ulmoides male flowers. Quercetin-3-O-sambubioside promotes the stimulation of the nerve center. Antioxidant and anticancer activities .

HY-N0667R

L-Asparagine (Standard)	Structural Classification Immune System Disorder Microorganisms Source classification Disease markers Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Endogenous Metabolite
L-Asparagine (Standard) is the analytical standard of L-Asparagine. This product is intended for research and analytical applications. L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity . In Vitro:L-Asparagine (0.03 mM) can reverse the proliferation decline of six human cancer cells induced by ASNS siRNA knockdown . L-Asparagine (10 mM, 4 h) can stimulate ODC activity and proliferation in IPEC-J2 cells .

HY-N12566

Erinacin B	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

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