oxaloacetate

By Targets:	ATP Citrate Lyase (2) Endogenous Metabolite (7)
By Research Areas:	Cancer (2) Metabolic Disease (10)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3016A

*Glutamate oxaloacetate* aminotransferase, porcine heart**	Endogenous Metabolite	Metabolic Disease
Glutamate oxaloacetate aminotransferase, porcine heart catalyzes the reversible reaction of L-aspartate and α-ketoglutarate into oxaloacetate and L-glutamate .

HY-E70015

Phosphoenolpyruvate carboxylase, Microorganism PEPC	Others	Others
Phosphoenolpyruvate carboxylase, Microorganism (PEPC) is a carbon dioxide fixing enzyme that in an irreversible manner and in the presence of Mg ²⁺, converts phosphoenolpyruvate and bicarbonate into oxaloacetate and inorganic phosphorus. Phosphoenolpyruvate carboxylase catalyses the primary assimilation of CO(2) in Crassulacean acid metabolism plants. Phosphoenolpyruvate carboxylase plays a major role in setting the day-night pattern of metabolism in plants .

HY-124825

iGOT1-01	Others	Cancer
iGOT1-01 is a potent *aspartate aminotransferase 1 (glutamate oxaloacetate* transaminase 1; GOT1) inhibitor. iGOT1-01 has IC₅₀**s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity .

HY-P2809

Malic dehydrogenase, microorganism MDH; EC 1.1.1.37	Endogenous Metabolite	Metabolic Disease
Malate dehydrogenase (EC 1.1.1.37) (MDH) catalyzes the mutual conversion of oxaloacetate and malate, and is associated with the oxidation/reduction of dinucleotide coenzymes .

HY-P2739

Citrate synthase	Others	Others
Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix .

HY-P2837

Oxaloacetate decarboxylase	Endogenous Metabolite	Metabolic Disease
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC₂. Oxaloacetate decarboxylase is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family. Oxaloacetate decarboxylase converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na ⁺ ions across the membrane .

HY-P3001

*Malate dehydrogenase oxaloacetate-decarboxylating, NADP+*	Others	Others
Malate dehydrogenase (oxaloacetate-decarboxylating, NADP+) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P3016B

Aspartate aminotransferase, Human liver GOT, Human liver; AST, Human liver	Endogenous Metabolite	Metabolic Disease
Aspartate aminotransferase (GOT), Human liver is an aminotransferase derived from human liver and is commonly used in biochemical research. Aspartate aminotransferase, Human liver catalyzes the conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate .

HY-P3016

Aspartate aminotransferase, Genetically engineered bacteria EC 2.6.1.1; GOT; AST	Endogenous Metabolite	Others
Aspartate aminotransferase, Genetically engineered bacteria (EC 2.6.1.1) (AST) is a transaminase enzyme, is often used in biochemical studies. Aspartate aminotransferase catalyzes aspartate and alpha-ketoglutarate converts to oxaloacetate and glutamate. Aspartate aminotransferase can be found in cerebrospinal fluid, exudates, and transudates .

HY-P2843

Citrate lyase	Endogenous Metabolite	Metabolic Disease
Citrate lyase is an enzyme that converts citrate to oxaloacetate .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-P2989

Pyruvate carboxylase	Endogenous Metabolite	Metabolic Disease
Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3 ⁻ and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells .

HY-122723

GOT1 inhibitor-1 2 Publications Verification	Others	Cancer
GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of *glutamate oxaloacetate* transaminase 1 (GOT1) with an IC₅₀** of 8.2 uM. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC) .

HY-163771

Pyruvate Carboxylase-IN-5	Others	Metabolic Disease
Pyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyruvate carboxylase is a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, a process that plays an important role in maintaining steady-state levels of Krebs cycle intermediates, which are precursors for the synthesis of biomacromolecules such as amino acids, fatty acids, and glucose .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard)	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

Cat. No.	Product Name	Target	Research Area

HY-P3469A

Dasiglucagon acetate	Peptides	Metabolic Disease
Dasiglucagon acetate is a human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

Cat. No.	Compare	Product Name	Species	Source

HY-P7611

	GOT1 Protein, Human (His) rHuGOT1, His; Glutamate oxaloacetate Transaminase 1; Transaminase A; GOT1	Human	E. coli
	GOT1 Protein, Human (His), a recombinant human GOT1 produced in E. coli, has a His tag. Calcitonin has an effect on decreasing osteoclast activity and has the potential for hypercalcemia research. Reduction in glutamate concentration in blood is induced through the activity of the blood-resident enzyme glutamate oxaloacetate transaminase 1 (GOT1), which catalyzes the reversible transformation of oxaloacetate and glutamate to aspartate and α-ketoglutarate.

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HY-P82430

	Aspartate Aminotransferase Antibody (YA2175) Aspartate aminotransferase; cytoplasmic; Glutamate oxaloacetate transaminase 1; Transaminase A	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Aspartate Aminotransferase Antibody (YA2175) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2175), targeting Aspartate Aminotransferase, with a predicted molecular weight of 46 kDa (observed band size: 46 kDa). Aspartate Aminotransferase Antibody (YA2175) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

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oxaloacetate

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