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p27kip1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (3) E1/E2/E3 Enzyme (2) Interleukin Related (1) NF-κB (1) Pim (2) Proteasome (1) PTEN (1) ROS Kinase (1) TNF Receptor (1)
By Research Areas:	Cancer (7) Inflammation/Immunology (1)

9

Inhibitors & Agonists

1

Peptides

1

Natural
Products

2

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

GGTI-2418	Apoptosis	Cancer
GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC₅₀s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors .

SJ572403 3 Publications Verification SJ403	Others	Others
SJ572403 (SJ403) is a *p27 ^Kip1* inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a K_d value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) .

GGTI-2417	ROS Kinase Apoptosis	Cancer
GGTI-2417 is a potent and selective inhibitor of GGTase I. GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27 ^Kip1 at Thr187 and accumulates p27 ^Kip1 in the nucleus. GGTI-2417 also induces breast cancer cell apoptosis .

CC0651	E1/E2/E3 Enzyme	Cancer
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently (IC₅₀=1.72 μM) inhibits the ubiquitination of p27 ^Kip1, as confirmed by dose-response analysis.

Pim-1/2 kinase inhibitor 1	Pim	Cancer
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and *p27 ^Kip1*. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer .

CEP1612	Proteasome Apoptosis	Cancer
CEP1612 is a dipeptidyl proteasome inhibitor with the IC₅₀ of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo .

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and *p27Kip1* degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .

NSC624206	E1/E2/E3 Enzyme	Cancer
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC₅₀ of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC₅₀=13 μM) but has no effect on ubiquitin adenylation .

Cat. No.	Product Name	Target	Research Area

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	CDKN1B Protein, Human (His) rHuCyclin-dependent kinase inhibitor 1B/CDKN1B, His; Cyclin-Dependent Kinase Inhibitor 1B; Cyclin-Dependent Kinase Inhibitor p27; p27kip1; CDKN1B; KIP1	Human	E. coli
	The CDKN1B protein is a key cell cycle regulator that inhibits CDK2 when bound to cyclin A, thereby inhibiting G1 phase progression. It exhibits significant inhibitory effects on cyclin E- and cyclin A-CDK2 complexes. CDKN1B Protein, Human (His) is the recombinant human-derived CDKN1B protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDKN1B Protein, Human (His) is 198 a.a., with molecular weight of ~30.0 kDa.

	LAMTOR1 Protein, Human (His) C11orf59; LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; LTOR1_HUMAN; p18; p27kip1-releasing factor from RhoA; p27RF-Rho; PDRO; PP7157; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; Ragulator1; RhoA activator C11orf59	Human	E. coli
	The LAMTOR1 protein is an important component of the Ragulator complex and plays dual roles in amino acid sensing and mTORC1 activation. It acts as a guanine nucleotide exchange factor (GEF) for Rag GTPases and mediates their recruitment to the lysosomal membrane. LAMTOR1 Protein, Human (His) is the recombinant human-derived LAMTOR1 protein, expressed by E. coli , with N-His labeled tag. The total length of LAMTOR1 Protein, Human (His) is 160 a.a., with molecular weight of ~24 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

	p27 KIP 1 Antibody	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
	p27 KIP 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 22 kDa, targeting to p27 KIP 1. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

	*Phospho-p27 Kip 1* (Ser10) Antibody (YA1494)** CDKN1B; KIP1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27kip1	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1494), targeting Phospho-p27 Kip 1 (Ser10), with a predicted molecular weight of 22 kDa (observed band size: 27 kDa). Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

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