pediatric

By Targets:	Adrenergic Receptor (5) Antibiotic (3) Antifolate (2) Bacterial (3) Endogenous Metabolite (4) Fungal (1) HDAC (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) Potassium Channel (5)
By Research Areas:	Cancer (7) Cardiovascular Disease (7) Endocrinology (1) Infection (3) Inflammation/Immunology (3) Neurological Disease (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0437

Sotalol hydrochloride 2 Publications Verification MJ 1999	Adrenergic Receptor Potassium Channel	Cardiovascular Disease Neurological Disease
Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

HY-B1782

Sulfamoxole	Bacterial Antibiotic	Infection
Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial agent. Sulfamoxole can be used for the study of pediatric infections .

HY-W016836

Metanilic acid	Endogenous Metabolite	Cancer
Metanilic acid, recognized for its anti-cancer properties, is utilized in the treatment of various malignancies, such as choriocarcinoma and pediatric acute lymphoblastic leukemia.

HY-W014130

N-Acetyl-L-arginine 1 Publications Verification Ac-Arg-OH	Endogenous Metabolite	Others
N-Acetyl-L-arginine (Ac-Arg-OH) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.

HY-14518

Aminopterin 4-Aminofolic acid; APGA	Antifolate	Inflammation/Immunology Cancer
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K_i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia .

HY-105529

Indicine N-oxide (+)-Indicine N-oxide; NSC 132319	Microtubule/Tubulin	Cancer
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research .

HY-103196

Sotalol	Adrenergic Receptor Potassium Channel	Cardiovascular Disease Neurological Disease
Sotalol is an orally active, non-selective β-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

HY-B0437R

Sotalol (hydrochloride) (Standard)	Adrenergic Receptor Potassium Channel	Cardiovascular Disease Neurological Disease
Sotalol (hydrochloride) (Standard) is the analytical standard of Sotalol (hydrochloride). This product is intended for research and analytical applications. Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

HY-B1782R

Sulfamoxole (Standard)	Bacterial Antibiotic	Infection
Sulfamoxole (Standard) is the analytical standard of Sulfamoxole. This product is intended for research and analytical applications. Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial agent. Sulfamoxole can be used for the study of pediatric infections .

HY-113086

CE(16:1(9Z)) 16:1(9Z) CE; 16:1(9Z) Cholesterol ester; Cholesterol Palmitoleate	Endogenous Metabolite	Cardiovascular Disease
Cholesteryl palmitoleate is a cholesterol ester. Plasma levels of cholesteryl palmitoleate are increased in ApoE-/- mice exposed to cigarette smoke and in pediatric patients with biliary atresia. Cholesteryl palmitoleate has been used as a standard for the identification of cholesterol esters in human meibomian gland secretions.

HY-B0437AS

Sotalol-d6 hydrochloride MJ 1999-d₆ hydrochloride	Adrenergic Receptor Potassium Channel	Cardiovascular Disease Endocrinology
Sotalol-d₆ (hydrochloride) is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is an orally active, non-selective competitive β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels[1][2].

HY-B0437S

Sotalol-d6 MJ 1999-d₆	Isotope-Labeled Compounds Adrenergic Receptor Potassium Channel	Cardiovascular Disease Neurological Disease
Sotalol-d₆ is the deuterium labeled Sotalol. Sotalol is an orally active, non-selective β-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent[1][2][3][4].

HY-14518R

Aminopterin (Standard)	Antifolate	Inflammation/Immunology Cancer
Aminopterin (Standard) is the analytical standard of Aminopterin. This product is intended for research and analytical applications. Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia .

HY-126562R

Piperlonguminine (Standard)	Bacterial Fungal Antibiotic	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Sotalol (hydrochloride) (Standard) is the analytical standard of Sotalol (hydrochloride). This product is intended for research and analytical applications. Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

HY-16505

Triclofos sodium	Endogenous Metabolite	Neurological Disease
Triclofos sodium is a drug used to suppress insomnia and for sedation and has sedative activity. Triclofos sodium is used in children for sedation during painless medical procedures, particularly in children with neurocognitive disorders. Triclofos sodium has similar physiological and pharmacological properties to chloral and therefore can be used as a substitute when necessary. The safety and efficacy of Triclofos sodium have been demonstrated in pediatric populations with high rates of neurocognitive disorders .

HY-143877

NN-390	HDAC	Cancer
NN-390 is a potent and selective HDAC6 inhibitor, with an IC₅₀ of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB). NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma) .

Cat. No.	Product Name

HY-L104

Pediatric Drug Library	682 compounds
The lack of availability of appropriate medicines for children is an extensive and urgent problem. A variety of obstacles hinder children's drug development, including the limited commercial interest, lack of suitable infrastructure and competence for conducting paediatric clinical trials, difficulties in trial design, ethical worries and many others. Because of these factors, unlicensed and off-label prescribing is very common in children which may lead to safety concern. MCE offers a unique collection of 682 Pediatric medicines, all of which have been approved or studied in clinical trials for children diseases. MCE children’s drug library is a useful tool for drug repurposing to discover new children’s indications.

Pediatric Drug Library

682 compounds

The lack of availability of appropriate medicines for children is an extensive and urgent problem. A variety of obstacles hinder children's drug development, including the limited commercial interest, lack of suitable infrastructure and competence for conducting paediatric clinical trials, difficulties in trial design, ethical worries and many others. Because of these factors, unlicensed and off-label prescribing is very common in children which may lead to safety concern.

MCE offers a unique collection of 682 Pediatric medicines, all of which have been approved or studied in clinical trials for children diseases. MCE children’s drug library is a useful tool for drug repurposing to discover new children’s indications.

Cat. No.	Product Name	Target	Research Area

HY-P9933

Dinutuximab APN-311	Inhibitory Antibodies	Cancer
Dinutuximab (Unituxin; APN-311) is a chimeric, human-murine, anti-GD2 monoclonal antibody. Dinutuximab potently enlongs event-free survival and overall survival, in high-risk neuroblastoma treatment, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), aldesleukin (interleukin-2 [IL-2]), and isotretinoin (13-cis-retinoic acid [RA]) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W014130

N-Acetyl-L-arginine 1 Publications Verification Ac-Arg-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Acetyl-L-arginine (Ac-Arg-OH) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.

HY-105529

Indicine N-oxide (+)-Indicine N-oxide; NSC 132319	Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Tournefortia argentea Linnaeus f. Source classification Plants Boraginaceae Disease Research Fields Cancer	Microtubule/Tubulin
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research .

HY-126562R

Piperlonguminine (Standard)	Alkaloids Structural Classification Capsicum annuum L. Other Alkaloids Source classification Solanaceae Plants	Bacterial Fungal Antibiotic
Sotalol (hydrochloride) (Standard) is the analytical standard of Sotalol (hydrochloride). This product is intended for research and analytical applications. Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .

Cat. No.	Product Name	Chemical Structure

HY-B0437AS

Sotalol-d6 hydrochloride
Sotalol-d₆ (hydrochloride) is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is an orally active, non-selective competitive β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels[1][2].

HY-B0437S

Sotalol-d6
Sotalol-d₆ is the deuterium labeled Sotalol. Sotalol is an orally active, non-selective β-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent[1][2][3][4].

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Inhibitors & Agonists

Screening Libraries

Inhibitory Antibodies

Natural
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Isotope-Labeled Compounds