2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Adrenergic Receptor Potassium Channel
  4. Sotalol hydrochloride

Sotalol hydrochloride  (Synonyms: MJ 1999)

Cat. No.: HY-B0437 Purity: 99.91%
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Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent.

For research use only. We do not sell to patients.

Sotalol hydrochloride Chemical Structure

Sotalol hydrochloride Chemical Structure

CAS No. : 959-24-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 In-stock
Solution
10 mM * 1 mL in DMSO USD 27 In-stock
Solid
5 mg USD 25 In-stock
10 mg USD 35 In-stock
50 mg USD 60 In-stock
100 mg USD 96 In-stock
200 mg USD 144 In-stock
500 mg USD 288 In-stock
1 g USD 384 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Sotalol hydrochloride:

Sotalol hydrochloride Related Antibodies

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Description

Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent[1][2][3].

IC50 & Target

β-adrenergic receptor[1]; Potassium channels[1]
In Vivo

Sotalol hydrochloride (MJ 1999) is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol hydrochloride does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol hydrochloride alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol hydrochloride (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-25 g female Swiss mice[3]
Dosage: 100 mg/kg
Administration: Administered intraperitoneally
Result: Significantly decreased the brain concentrations of Lamotrigine and increased those of Oxcarbazepine and Topiramate.
Molecular Weight

308.82

Formula

C12H21ClN2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=C(NS(C)(=O)=O)C=C1)CNC(C)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (323.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (323.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2381 mL 16.1907 mL 32.3813 mL
5 mM 0.6476 mL 3.2381 mL 6.4763 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 110 mg/mL (356.19 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.91%

COA (248 KB) LCMS (100 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.2381 mL 16.1907 mL 32.3813 mL 80.9533 mL
5 mM 0.6476 mL 3.2381 mL 6.4763 mL 16.1907 mL
10 mM 0.3238 mL 1.6191 mL 3.2381 mL 8.0953 mL
15 mM 0.2159 mL 1.0794 mL 2.1588 mL 5.3969 mL
20 mM 0.1619 mL 0.8095 mL 1.6191 mL 4.0477 mL
25 mM 0.1295 mL 0.6476 mL 1.2953 mL 3.2381 mL
30 mM 0.1079 mL 0.5397 mL 1.0794 mL 2.6984 mL
40 mM 0.0810 mL 0.4048 mL 0.8095 mL 2.0238 mL
50 mM 0.0648 mL 0.3238 mL 0.6476 mL 1.6191 mL
60 mM 0.0540 mL 0.2698 mL 0.5397 mL 1.3492 mL
80 mM 0.0405 mL 0.2024 mL 0.4048 mL 1.0119 mL
100 mM 0.0324 mL 0.1619 mL 0.3238 mL 0.8095 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sotalol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sotalol959-24-0MJ 1999MJ1999MJ-1999Adrenergic ReceptorPotassium ChannelBeta ReceptorKcsAantiepilepticPharmacodynamic,Antiarrhythmicpediatricarrhythmiasβ-receptorpotassiumKCNH2channelInhibitorinhibitorinhibit

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