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Results for "

phase-II

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Inhibitory Antibodies

6

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16997A
    Itacitinib adipate
    10+ Cited Publications

    		 JAK Cancer
    Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.
    Itacitinib adipate
  • HY-115772
    4′-Bromoflavone

    		Others Cancer
    4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer .
    4′-Bromoflavone
  • HY-P99954
    Rivabazumab pegol

    		Bacterial Infection
    Rivabazumab pegol is a PcrV protein antibody that can be used to study the phase II pegylated Fab of chronic Pseudomonas aeruginosa infection .
    Rivabazumab pegol
  • HY-116029
    Tolmetin β-D-Glucuronide

    Tolmetin glucuronide

    		 Drug Metabolite Inflammation/Immunology Cancer
    Tolmetin β-D-Glucuronide (Tolmetin glucuronide) is the major phase II metabolite of Tolmetin (HY-B1799) .
    Tolmetin β-D-Glucuronide
  • HY-14955A
    (Rac)-Managlinat dialanetil

    (Rac)-MB06322; (Rac)-CS-917

    		 Others Others
    (Rac)-Managlinat dialanetil ((Rac)-MB06322) is a compound for the inhibition of type 2 diabetes that is in Phase II clinical trials and works by inhibiting gluconeogenesis.
    (Rac)-Managlinat dialanetil
  • HY-133078
    Thienyldecyl Isothiocyanate

    		Cytochrome P450 Cancer
    Thienyldecyl isothiocyanate is an analog of thienylbutyl isothiocyanate that, like many isothiocyanates, demonstrates antiproliferative activity against cancer cells presumably by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes.
    Thienyldecyl Isothiocyanate
  • HY-N10344
    Glucoarabin

    		Cytochrome P450 Cancer
    Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity .
    Glucoarabin
  • HY-N14116
    Garlic oil

    		Apoptosis Reactive Oxygen Species Cancer
    Garlic oil contains various organosulfur compounds with anticancer activities. Garlic oil can significantly activate apoptosis in lung tissue induced by NNK (HY-126477). Furthermore, Garlic oil can markedly reduce NNK-induced DNA damage and prevent the occurrence of lung cancer by inducing the expression of phase II drug-metabolizing enzymes (HO-1, NQO-1, and GSTA1) .
    Garlic oil
  • HY-N1902R
    4-Hydroxyphenylacetic acid (Standard)

    		Keap1-Nrf2 Endogenous Metabolite Metabolic Disease
    4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 . IC50 & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .
    4-Hydroxyphenylacetic acid (Standard)
  • HY-N6802
    Tigloylgomisin H

    		Keap1-Nrf2 Cancer
    Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent .
    Tigloylgomisin H
  • HY-W721119
    7-Methylsulfinylheptyl isothiocyanate

    		p38 MAPK Autophagy Inflammation/Immunology Cancer
    7-Methylsulfinylheptyl isothiocyanate is an activator for MAPK signaling pathway, which downregulates the melanogenesis related proteins and suppresses the melanin synthesis in B16-F1 cells. 7-Methylsulfinylheptyl isothiocyanate induces autophagy. 7-Methylsulfinylheptyl isothiocyanate is an inducer for phase II enzyme, which exhibits chemoprotective effect against carcinogen. 7-Methylsulfinylheptyl isothiocyanate can be used as cosmetic ingredient for skin whitening and anti-inflammation .
    7-Methylsulfinylheptyl isothiocyanate
  • HY-13755A
    (R)-Sulforaphane

    L-Sulforaphane

    		 Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species NF-κB Inflammation/Immunology Cancer
    (R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses .
    (R)-Sulforaphane

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