serotonergic systems

By Targets:	5-HT Receptor (2) Adrenergic Receptor (1) Apoptosis (1) Dopamine Receptor (1) Fluorescent Dye (1) iGluR (1) Monoamine Oxidase (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Neurological Disease (4)

Targets Recommended: Complement System

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100938

m-CPBG hydrochloride 1-(3-Chlorophenyl)biguanide hydrochloride	5-HT Receptor	Neurological Disease
m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT₃ agonist. m-CPBG hydrochloride can be used for the research of neurological disease .

HY-Y0265

Isatin Indoline-2,3-dione	Monoamine Oxidase Apoptosis	Cardiovascular Disease Neurological Disease Cancer
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-D2335

SERTlight	Fluorescent Dye	Neurological Disease
SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB_5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems .

HY-19225A

Ensaculin free base KA-672; Anseculin	iGluR 5-HT Receptor Adrenergic Receptor Dopamine Receptor	Neurological Disease
Ensaculin free base (KA-672) is a NMDA antagonist and have high affinities to serotonergic 5-HT_1A and 5-HT₇ receptors, adrenergic α₁, and dopaminergic D₂ and D₃ receptors. Ensaculin free base is a memory-enhancing agent. Ensaculin free base has the potential as an antidementia agent acting on various transmitter systems .

Cat. No.	Product Name	Type

HY-D2335

SERTlight	Dyes
SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB_5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems .

SERTlight

Dyes

SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB_5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0265

Isatin Indoline-2,3-dione	Cardiovascular Disease Alkaloids other families Classification of Application Fields Neurological Disease Source classification Plants Disease Research Fields Indole Alkaloids	Monoamine Oxidase Apoptosis
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

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serotonergic systems

Inhibitors & Agonists

Fluorescent Dye

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