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Results for "

superoxide anion generation

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

5

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N10450
    Kumujian A

    1-Ethoxycarbonyl-β-carboline

    		 Reactive Oxygen Species Inflammation/Immunology
    Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL) .
    Kumujian A
  • HY-N8217
    4-O-Cinnamoylquinic acid

    		Others Inflammation/Immunology
    4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .
    4-O-Cinnamoylquinic acid
  • HY-U00005
    AD 0261

    		Reactive Oxygen Species Inflammation/Immunology
    AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.
    AD 0261
  • HY-156468
    Antioxidant agent-17

    		Others Inflammation/Immunology
    Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC50 of 9.06 nM .
    Antioxidant agent-17
  • HY-N11564
    Aristololactam IIIa

    		Elastase Inflammation/Immunology
    Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively .
    Aristololactam IIIa
  • HY-N8447
    3'-O-Methylmurraol

    		Others Others
    3'-O-Methylmurraol is a coumarinthat can be found in Cnidium monnieri. 3'-O-Methylmurraol inhibits superoxide radical anion generation and elastase release .
    3'-O-Methylmurraol
  • HY-126603
    Asperlactone

    		Endogenous Metabolite Infection
    Asperlactone has anti-inflammatory activity. Asperlactone inhibits superoxide anion generation. Asperlactone is a fungal metabolite that can be isolated from isolated from Aspergillus ochraceus .
    Asperlactone
  • HY-132132
    Neutrophil elastase inhibitor 3

    		Elastase Inflammation/Immunology
    Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release .
    Neutrophil elastase inhibitor 3
  • HY-116730
    CHS-111

    		Reactive Oxygen Species Others
    CHS-111 is a benzyl indazole inhibitor of superoxide anion O 2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC50 of 3.9 μM .
    CHS-111
  • HY-156241
    Meliadubin B

    		NO Synthase Fungal Infection Inflammation/Immunology
    Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC50 of 182.50 μM.
    Meliadubin B
  • HY-101283
    HCH6-1
    3 Publications Verification

    		 Formyl Peptide Receptor (FPR) Inflammation/Immunology
    HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
    HCH6-1
  • HY-121586
    Nafazatrom

    Bay g 6575

    		 Lipoxygenase Cardiovascular Disease
    Nafazatrom (Bay g 6575) is an orally active cardioprotective agent that protects against ischemic damage. Nafazatrom dose-dependently inhibits neutrophil aggregation, superoxide anion generation, arachidonic acid metabolism, and to a lesser extent the release of β-glucosidase, platelet aggregation or arachidonic acid in vitro. Acid metabolism has no significant effect. In a dog ischemia-reperfusion model, Nafazatrom (10 mg/kg; po) reduced infarct size and the occurrence of arrhythmias and rescued ischemic myocardial function without affecting any hemodynamic changes. The basis of Nafazatrom's cardioprotection may be inhibition of neutrophil function and cellular infiltration in vitro .
    Nafazatrom

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