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toll-like receptor 3

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By Targets:	Toll-like Receptor (TLR) (7) Amyloid-β (1) Apoptosis (3) ATM/ATR (1) Bcl-2 Family (1) HSP (1) Interleukin Related (1) Phosphatase (1) PKD (1)
By Research Areas:	Cancer (4) Infection (3) Inflammation/Immunology (5) Neurological Disease (1)

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Inhibitors & Agonists

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Natural
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2

Recombinant Proteins

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Antibodies

Targets Recommended: Toll-like Receptor (TLR) Polo-like Kinase (PLK) NOD-like Receptor (NLR) KLF ANGPTL PERK ULK METTL3 MASTL ADAMTS IGF-1R LOX-1 Nuclear Hormone Receptor 4A/NR4A FLT3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Polyinosinic acid sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Polyinosinic acid sodium is the sodium form of Polyinosinic acid (HY-148980). Polyinosinic acid is a single stranded homonucleic acid, which is a **Toll-like Receptor 3 (TLR3**) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation .

Poly (I:C):Kanamycin (1:1) Maximum Cited Publications 17 Publications Verification	Toll-like Receptor (TLR)	Infection
Poly (I:C):Kanamycin (1:1) is a mixture of poly (I:C) and kanamycin. Poly(I:C) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Kanamycin is positively charged (poly-NH3) and can thus neutralize the negative charge of Poly I:C and thereby stabilized the molecule.

Polyinosinic-polycytidylic acid sodium Maximum Cited Publications 17 Publications Verification Poly(I:C) sodium	Toll-like Receptor (TLR) Apoptosis	Inflammation/Immunology Cancer
Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis .

Polyinosinic-polycytidylic acid Maximum Cited Publications 17 Publications Verification Poly(I:C)	Toll-like Receptor (TLR) PKD HSP Bcl-2 Family Interleukin Related	Infection Inflammation/Immunology Cancer
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .

Ro 90-7501 2 Publications Verification	Amyloid-β ATM/ATR Phosphatase Apoptosis	Neurological Disease Cancer
Ro 90-7501 is an amyloid β₄₂ (Aβ₄₂) fibril assembly inhibitor that reduces Aβ₄₂-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .

Guignardone L	Toll-like Receptor (TLR)	Infection
Guignardone L is a metabolite isolated from the endophytic fungus Guignardia mangiferae with toll-like receptor 3 regulating activity .

Polyinosinic acid	Toll-like Receptor (TLR)	Inflammation/Immunology
Polyinosinic acid is a single stranded homonucleic acid, which is a **Toll-like Receptor 3 (TLR3**) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation .

Polyinosinic-polycytidylic acid potassium Poly(I:C) potassium	Toll-like Receptor (TLR) Apoptosis	Inflammation/Immunology Cancer
Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid potassium can directly trigger cancer cells to undergoApoptosis .

Species:	Mouse (2)
Tag:	His (2)
Source:	HEK293 (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

	TLR3 Protein, Mouse (sf9, His) toll-like receptor 3; CD283; Tlr3	Mouse	Sf9 insect cells
	TLR3 protein is an important component of innate and adaptive immunity and can recognize pathogen-associated molecular patterns and activate NF-κ-B, IRF3 and cytokine secretion. Ligand binding induces TLR3 dimerization, and efficient signal transduction requires clustering of signaling units along the ligand. TLR3 Protein, Mouse (sf9, His) is the recombinant mouse-derived TLR3 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TLR3 Protein, Mouse (sf9, His) is 677 a.a., with molecular weight of 75-80 kDa.

	TLR3 Protein, Mouse (705a.a, HEK293, His) toll-like receptor 3; CD283; Tlr3	Mouse	HEK293
	TLR3 protein is an important component of innate and adaptive immunity and can recognize pathogen-associated molecular patterns and activate NF-κ-B, IRF3 and cytokine secretion. Ligand binding induces TLR3 dimerization, and efficient signal transduction requires clustering of signaling units along the ligand. TLR3 Protein, Mouse (705a.a, HEK293, His) is the recombinant mouse-derived TLR3 protein, expressed by HEK293 , with C-His labeled tag.

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	Toll-Like Receptor 3 Antibody CD283; CD283 antigen; IIAE2; TLR 3; Tlr3; TLR3_HUMAN; toll like receptor 3; toll-like receptor 3.	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat
	Toll-Like Receptor 3 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 105 kDa, targeting to Toll-Like Receptor 3 . It can be used for WB, IHC-P, IHC-F, IF, ELISA assays with tag free, in the background of Human, Mouse, Rat.

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