2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Epoxide Hydrolase Cholinesterase (ChE)
  4. sEH/AChE-IN-3

sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively.

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sEH/AChE-IN-3 Chemical Structure

sEH/AChE-IN-3 Chemical Structure

CAS No. : 2490589-11-0

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sEH/AChE-IN-3 Related Antibodies

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Description

sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1].

IC50 & Target

IC50: 0.4 nM (hsEH), 1.94 ± 0.67 nM (hAChE), 615 ± 34 nM (hBChE), 4.3 nM (msEH), 2.61 ± 0.16 nM (mAChE)[1]
Molecular Weight

670.16

Formula

C35H39ClF3N5O3
CAS No.
SMILES

O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CCCCNC3=C([C@]4([H])CC(C)=C[C@](C4)([H])C5)C5=NC6=CC(Cl)=CC=C36)=O)CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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sEH/AChE-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sEH/AChE-IN-32490589-11-0Epoxide HydrolaseCholinesterase (ChE)SH-SY5Y cellsBBB permeabilitylow neurotoxicityAlzheimer’s diseasesoluble epoxide hydrolaseneuroinflammationmemory impairmentInhibitorinhibitorinhibit

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