2. Immunology/Inflammation
  3. NOD-like Receptor (NLR) Interleukin Related
  4. Selnoflast

Selnoflast  (Synonyms: Somalix; RO-7486967; IZD334)

Cat. No.: HY-132831 Purity: 99.46%
SDS COA Handling Instructions Technical Support

Selnoflast (RO7486967), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease

For research use only. We do not sell to patients.

Selnoflast Chemical Structure

Selnoflast Chemical Structure

CAS No. : 2260969-36-4

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Selnoflast:

Selnoflast Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Selnoflast

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Isoforms
NLRP3 NLRP1 NOD1 NOD2

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Selnoflast (RO7486967), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease[1][2][3][4][5]

IC50 & Target

NLRP3

 

Molecular Weight

391.53

Formula

C20H29N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NS(=O)(C1CCN(CC1)CC)=O)NC2=C(CCC3)C3=CC4=C2CCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (12.77 mM; ultrasonic and adjust pH to 8 with 1M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

1M NaOH : 3.33 mg/mL (8.51 mM; adjust pH to 12 with 1M NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5541 mL 12.7704 mL 25.5408 mL
5 mM 0.5108 mL 2.5541 mL 5.1082 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.46%

SDS (252 KB)

COA (251 KB) HNMR (135 KB) RP-HPLC (169 KB) LCMS (385 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M NaOH / DMSO 1 mM 2.5541 mL 12.7704 mL 25.5408 mL 63.8521 mL
5 mM 0.5108 mL 2.5541 mL 5.1082 mL 12.7704 mL
DMSO 10 mM 0.2554 mL 1.2770 mL 2.5541 mL 6.3852 mL
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Selnoflast Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selnoflast2260969-36-4Somalix RO-7486967 IZD334RO7486967RO 7486967RO-7486967IZD334IZD 334IZD-334NOD-like Receptor (NLR)Interleukin RelatedILorally activereversibleNLRP3 inhibitorIL-1β inhibitorAlzheimer's diseaseulcerative colitischronic obstructive pulmonary diseasemacrophagesInhibitorinhibitorinhibit

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