2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Selurampanel

Selurampanel  (Synonyms: BGG 492)

Cat. No.: HY-105860 Purity: 99.41%
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Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research.

For research use only. We do not sell to patients.

Selurampanel Chemical Structure

Selurampanel Chemical Structure

CAS No. : 912574-69-7

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1 mg USD 230 In-stock
5 mg USD 540 In-stock
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Based on 1 publication(s) in Google Scholar

Selurampanel Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research[1][2].

In Vivo

Selurampanel (Compound 1S) potently and dose-dependently antagonizes maximal electroshock seizure (MES)-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment[1].
In a study with a 3 mg/kg i.v. dose, a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min▪kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

377.42

Formula

C16H19N5O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=C(C2=CC=NN2C)C=C3C(NC(N(NS(C)(=O)=O)C3=O)=O)=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 27.5 mg/mL (72.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6496 mL 13.2478 mL 26.4957 mL
5 mM 0.5299 mL 2.6496 mL 5.2991 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6496 mL 13.2478 mL 26.4957 mL 66.2392 mL
5 mM 0.5299 mL 2.6496 mL 5.2991 mL 13.2478 mL
10 mM 0.2650 mL 1.3248 mL 2.6496 mL 6.6239 mL
15 mM 0.1766 mL 0.8832 mL 1.7664 mL 4.4159 mL
20 mM 0.1325 mL 0.6624 mL 1.3248 mL 3.3120 mL
25 mM 0.1060 mL 0.5299 mL 1.0598 mL 2.6496 mL
30 mM 0.0883 mL 0.4416 mL 0.8832 mL 2.2080 mL
40 mM 0.0662 mL 0.3312 mL 0.6624 mL 1.6560 mL
50 mM 0.0530 mL 0.2650 mL 0.5299 mL 1.3248 mL
60 mM 0.0442 mL 0.2208 mL 0.4416 mL 1.1040 mL
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Selurampanel Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selurampanel912574-69-7BGG 492BGG492BGG-492iGluRIonotropic glutamate receptorsAMPAblood-brainbarrieroralepilepsyInhibitorinhibitorinhibit

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