2. Neuronal Signaling
  3. Tau Protein
  4. Semorinemab

Semorinemab  (Synonyms: RG 6100; RO7105705; MTAU-9937A)

Cat. No.: HY-P99399 Purity: 99.90%
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Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease.

For research use only. We do not sell to patients.

CAS No. : 2159141-27-0

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1 mg USD 300 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

Semorinemab Related Antibodies

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Description

Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Chimeric; Humanized
In Vitro

Semorinemab binds to human Tau and recombinant cynomolgus monkey Tau with Kd values of 3.8 and 11.2 nM, respectively[1].
Semorinemab prevents neurons to uptake oligomeric Tau[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Semorinemab Related Antibodies
In Vivo

Semorinemab (3, 10 and 30 mg/kg; i.p., once weekly for 13 weeks) reduces accumulation of Tau pathology in a transgenic (Tg) mouse model of tauopathy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg) [1]
Dosage: 3, 10 and 30 mg/kg
Administration: Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks
Result: Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Semorinemab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human Tau Protein (His Tag) can bind Semorinemab. The EC50 for this effect is 4.02 ng/mL.
Purity & Documentation
References
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Semorinemab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Semorinemab2159141-27-0RG 6100 RO7105705 MTAU-9937ARG6100RG-6100RO7105705RO 7105705RO-7105705Tau ProteinantibodyAlzheimer's Diseasecynomolgus monkeyneuronmiceInhibitorinhibitorinhibit

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