2. Others GPCR/G Protein Metabolic Enzyme/Protease Neuronal Signaling
  3. Isotope-Labeled Compounds 5-HT Receptor COMT Endogenous Metabolite
  4. Serotonin-d4

Serotonin-d4  (Synonyms: 5-Hydroxytryptamine-d4; 5-HT-d4)

Cat. No.: HY-B1473AS Purity: 99.60%
SDS COA Handling Instructions

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Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

For research use only. We do not sell to patients.

Serotonin-d<sub>4</sub> Chemical Structure

Serotonin-d4 Chemical Structure

CAS No. : 58264-95-2

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5 mg USD 480 In-stock
10 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

Serotonin-d4 Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Serotonin-d4 Related Antibodies
Molecular Weight

180.24

Formula

C10H8D4N2O
CAS No.
Unlabeled CAS

50-67-9
Appearance

Solid

Color

Off-white to gray

SMILES

NC([2H])([2H])C([2H])([2H])C(C1=C2)=CNC1=CC=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (554.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5482 mL 27.7408 mL 55.4816 mL
5 mM 1.1096 mL 5.5482 mL 11.0963 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.60%

SDS (644 KB)

COA (252 KB) HNMR (227 KB) LCMS (117 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.5482 mL 27.7408 mL 55.4816 mL 138.7039 mL
5 mM 1.1096 mL 5.5482 mL 11.0963 mL 27.7408 mL
10 mM 0.5548 mL 2.7741 mL 5.5482 mL 13.8704 mL
15 mM 0.3699 mL 1.8494 mL 3.6988 mL 9.2469 mL
20 mM 0.2774 mL 1.3870 mL 2.7741 mL 6.9352 mL
25 mM 0.2219 mL 1.1096 mL 2.2193 mL 5.5482 mL
30 mM 0.1849 mL 0.9247 mL 1.8494 mL 4.6235 mL
40 mM 0.1387 mL 0.6935 mL 1.3870 mL 3.4676 mL
50 mM 0.1110 mL 0.5548 mL 1.1096 mL 2.7741 mL
60 mM 0.0925 mL 0.4623 mL 0.9247 mL 2.3117 mL
80 mM 0.0694 mL 0.3468 mL 0.6935 mL 1.7338 mL
100 mM 0.0555 mL 0.2774 mL 0.5548 mL 1.3870 mL
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Serotonin-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Serotonin-d458264-95-25-Hydroxytryptamine-d4 5-HT-d4Isotope-Labeled Compounds5-HT ReceptorCOMTEndogenous MetaboliteSerotonin Receptor5-hydroxytryptamine ReceptorCatechol-O-methyltransferaseInhibitorinhibitorinhibit

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