SEW84 (Synonyms: SEW04784)

Cat. No.: HY-152184: FAQs
Data Sheet Handling Instructions

Molarity Calculator

For research use only. We do not sell to patients.

SEW84 Chemical Structure

CAS No. : 259089-67-3

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All HSP Isoform Specific Products:

View All Isoforms

HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

Biological Activity
Purity & Documentation
References
Customer Review

IC₅₀ & Target

IC50: 0.3 μM (ASH); 1.3 μM (GR-dependent luciferase expression); 0.7 μM (AR-dependent luciferase expression)^[1]

In Vitro

SEW84 (5 μM) shows complete inhibition of ASH activity with an IC₅₀ value of 0.3 μM^[1].
SEW84 inhibited the GR- and AR-dependent luciferase expression with IC₅₀ values of 1.3 and 0.7 μM, respectively^[1].
SEW84 (0-20 μM) inhibits the Hsp90-Dependent folding of firefly luciferase^[1].
SEW84 (0, 3, 10, 30 μM; 24 h) specifically clears phosphorylated tau^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	tau-0N4R-HeLa cells
Concentration:	0, 3, 10, 30 μM
Incubation Time:	24 h
Result:	Reduced the expression of phospho-Tau.

Immunofluorescence^[1]

Cell Line:	RFP-tau-0N4R HEK cells
Concentration:	1, 10 μM
Incubation Time:	24 h
Result:	Completely abrogated the aggregation of tau.

Cell Proliferation Assay^[1]

Cell Line:	LNCaP and 22Rv1 cells
Concentration:	0-100 μM
Incubation Time:	24 h
Result:	Observed a synergistic decrease in LNcaP cell proliferation when combined 1 μM GA with 10 μM SEw84.

Molecular Weight

422.40

Formula

C₁₉H₁₄F₄N₄OS

CAS No.

259089-67-3

SMILES

O=C(C1=CC=CN1C2=CC=C(C=C2)F)NNC(NC3=CC=CC(C(F)(F)F)=C3)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jay K Singh, et al. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chem Biol. 2020 Mar 19;27(3):292-305.e6. [Content Brief]

SEW84 Related Classifications

Metabolic Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEW84259089-67-3SEW04784SEW 84SEW-84SEW 04784SEW-04784HSPHeat shock proteinsAha1stimulated Hsp90 (ASH)ATPaseproteostatic diseaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks