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SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)–associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia.

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SGF29-IN-1 Chemical Structure

SGF29-IN-1 Chemical Structure

CAS No. : 6638-82-0

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Based on 1 publication(s) in Google Scholar

SGF29-IN-1 Related Antibodies

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Description

SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)–associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia[1].

In Vitro

SGF29-IN-1 (20 μM) inhibits Tudor domain of SGF29, blocks acetylation of H3K9 in SGF29-dependent leukemia cells MOLM13 and MV4-11[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGF29-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: MOLM13 and MV4-11
Concentration: 20 μM
Incubation Time: 48 h
Result: Inhibited acetylation of H3K9 and levels of RPL8 and RPS2.
In Vivo

SGF29-IN-1 (5 mg/kg, i.p. every other day for 35 days) inhibits leukemia progression without significant toxicity in CD45 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MLL-AF9 xenograft CD45 mice[1]
Dosage: 5 mg/kg
Administration: i.p., every other day for 35 days
Result: Reduced percentage of 45.2 cells in peripheral blood and spleen. Improved survival rate of rats.
Molecular Weight

519.63

Formula

C33H33N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1(CN2COC3=C(C2)C4=C(CN(CC5=CC=CC=C5)CO4)C6=C3CN(CO6)CC7=CC=CC=C7)=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1 M HCL : 25 mg/mL (48.11 mM; Need ultrasonic)

DMSO : 9.52 mg/mL (18.32 mM; ultrasonic and warming and adjust pH to 7 with 1 M HCL and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9244 mL 9.6222 mL 19.2445 mL
5 mM 0.3849 mL 1.9244 mL 3.8489 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1 M HCL 1 mM 1.9244 mL 9.6222 mL 19.2445 mL 48.1112 mL
5 mM 0.3849 mL 1.9244 mL 3.8489 mL 9.6222 mL
10 mM 0.1924 mL 0.9622 mL 1.9244 mL 4.8111 mL
15 mM 0.1283 mL 0.6415 mL 1.2830 mL 3.2074 mL
1 M HCL 20 mM 0.0962 mL 0.4811 mL 0.9622 mL 2.4056 mL
25 mM 0.0770 mL 0.3849 mL 0.7698 mL 1.9244 mL
30 mM 0.0641 mL 0.3207 mL 0.6415 mL 1.6037 mL
40 mM 0.0481 mL 0.2406 mL 0.4811 mL 1.2028 mL
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SGF29-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGF29-IN-16638-82-0OthersLeukemiatudor domainMOLM13MV4-11CD45 mouseInhibitorinhibitorinhibit

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