2. Metabolic Enzyme/Protease
  3. SGK
  4. SGK1-IN-3

SGK1-IN-3 (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 has the potential for the research of osteoarthritis.

For research use only. We do not sell to patients.

SGK1-IN-3 Chemical Structure

SGK1-IN-3 Chemical Structure

CAS No. : 2891696-18-5

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Other Forms of SGK1-IN-3:

SGK1-IN-3 Related Antibodies

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SGK1 SGK3

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Description

SGK1-IN-3 (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 has the potential for the research of osteoarthritis[1].

IC50 & Target

SGK1

 

Molecular Weight

531.41

Formula

C23H20Cl2N6O3S
CAS No.
SMILES

O=C(C1=CC(C2=CC=C(C=C2)NS(=O)(C3=C(C(Cl)=CC=C3)Cl)=O)=NC4=C1C=NN4)N[C@@H]5CCNC5
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SGK1-IN-3 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGK1-IN-32891696-18-5SGKSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseoralSGK1β-catenincartilage degradationosteoarthritisInhibitorinhibitorinhibit

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