2. Metabolic Enzyme/Protease
  3. SGK
  4. SGK1-IN-3 hydrochloride

SGK1-IN-3 hydrochloride (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride has the potential for the research of osteoarthritis.

For research use only. We do not sell to patients.

SGK1-IN-3 hydrochloride Chemical Structure

SGK1-IN-3 hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 780 In-stock
100 mg USD 1250 In-stock
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Other Forms of SGK1-IN-3 hydrochloride:

SGK1-IN-3 hydrochloride Related Antibodies

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Description

SGK1-IN-3 hydrochloride (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride has the potential for the research of osteoarthritis[1].

Molecular Weight

567.88

Formula

C23H21Cl3N6O3S
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC(C2=CC=C(C=C2)NS(=O)(C3=C(C(Cl)=CC=C3)Cl)=O)=NC4=C1C=NN4)N[C@@H]5CCNC5.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (220.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7609 mL 8.8047 mL 17.6094 mL
5 mM 0.3522 mL 1.7609 mL 3.5219 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7609 mL 8.8047 mL 17.6094 mL 44.0234 mL
5 mM 0.3522 mL 1.7609 mL 3.5219 mL 8.8047 mL
10 mM 0.1761 mL 0.8805 mL 1.7609 mL 4.4023 mL
15 mM 0.1174 mL 0.5870 mL 1.1740 mL 2.9349 mL
20 mM 0.0880 mL 0.4402 mL 0.8805 mL 2.2012 mL
25 mM 0.0704 mL 0.3522 mL 0.7044 mL 1.7609 mL
30 mM 0.0587 mL 0.2935 mL 0.5870 mL 1.4674 mL
40 mM 0.0440 mL 0.2201 mL 0.4402 mL 1.1006 mL
50 mM 0.0352 mL 0.1761 mL 0.3522 mL 0.8805 mL
60 mM 0.0293 mL 0.1467 mL 0.2935 mL 0.7337 mL
80 mM 0.0220 mL 0.1101 mL 0.2201 mL 0.5503 mL
100 mM 0.0176 mL 0.0880 mL 0.1761 mL 0.4402 mL
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SGK1-IN-3 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGK1-IN-3SGKSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseoralSGK1β-catenincartilage degradationosteoarthritisInhibitorinhibitorinhibit

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