SGK1-IN-3 hydrochloride

Cat. No.: HY-142686A Purity: 96.65%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SGK1-IN-3 hydrochloride (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride has the potential for the research of osteoarthritis.

For research use only. We do not sell to patients.

SGK1-IN-3 hydrochloride Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of SGK1-IN-3 hydrochloride:

SGK1-IN-3 Get quote

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SGK1 SGK3

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

567.88

Formula

C₂₃H₂₁Cl₃N₆O₃S

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC(C2=CC=C(C=C2)NS(=O)(C3=C(C(Cl)=CC=C3)Cl)=O)=NC4=C1C=NN4)N[C@@H]5CCNC5.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (220.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7609 mL	8.8047 mL	17.6094 mL
5 mM	0.3522 mL	1.7609 mL	3.5219 mL
10 mM	0.1761 mL	0.8805 mL	1.7609 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.65%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (256 KB) HNMR (282 KB) RP-HPLC (248 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Halland N, et al. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem. 2022;65(2):1567-1584. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7609 mL	8.8047 mL	17.6094 mL	44.0234 mL
	5 mM	0.3522 mL	1.7609 mL	3.5219 mL	8.8047 mL
	10 mM	0.1761 mL	0.8805 mL	1.7609 mL	4.4023 mL
	15 mM	0.1174 mL	0.5870 mL	1.1740 mL	2.9349 mL
	20 mM	0.0880 mL	0.4402 mL	0.8805 mL	2.2012 mL
	25 mM	0.0704 mL	0.3522 mL	0.7044 mL	1.7609 mL
	30 mM	0.0587 mL	0.2935 mL	0.5870 mL	1.4674 mL
	40 mM	0.0440 mL	0.2201 mL	0.4402 mL	1.1006 mL
	50 mM	0.0352 mL	0.1761 mL	0.3522 mL	0.8805 mL
	60 mM	0.0293 mL	0.1467 mL	0.2935 mL	0.7337 mL
	80 mM	0.0220 mL	0.1101 mL	0.2201 mL	0.5503 mL
	100 mM	0.0176 mL	0.0880 mL	0.1761 mL	0.4402 mL